ZNF493 Inhibitors
Chemical inhibitors of ZNF493 can exert their inhibitory effects through various mechanisms by targeting specific kinases and signaling pathways that are essential for the functional activity of the protein. Staurosporine, a broad-spectrum kinase inhibitor, can inhibit the protein kinases responsible for the phosphorylation of ZNF493, which is a critical post-translational modification required for its activation. Similarly, LY294002, a PI3K inhibitor, disrupts the PI3K/AKT signaling pathway, impairing the phosphorylation and consequently the functional activity of ZNF493. The MEK inhibitor PD98059 can hinder the ERK/MAPK pathway, reducing the phosphorylation of proteins in this signaling cascade, which includes ZNF493, thereby inhibiting its functional response. Rapamycin, by inhibiting mTOR, influences the PI3K/AKT/mTOR pathway, which plays a role in regulating protein synthesis and could lead to the functional inhibition of ZNF493.
Furthermore, SB203580's inhibition of p38 MAP Kinase can prevent the signaling that may activate ZNF493, while U0126's inhibition of MEK1/2 similarly suppresses the ERK/MAPK pathway's influence on ZNF493's activity. The PI3K inhibitor Wortmannin also interrupts signaling pathways critical for ZNF493's phosphorylation, while SP600125, a JNK inhibitor, can block signaling pathways that are implicated in the regulation of ZNF493's functional activity. Moreover, Y-27632 inhibition of ROCK potentially alters downstream signaling necessary for ZNF493's role in cellular processes. Gefitinib's targeting of EGFR disrupts upstream signals that converge on pathways regulating ZNF493. Further disruption of cell cycle-related processes by VX-680's inhibition of Aurora kinases and Palbociclib's inhibition of CDK4/6 could also lead to the suppression of ZNF493's function within these cellular contexts, as these processes can be important for the proper activity and regulation of ZNF493.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, and though it is general in its action, it can functionally inhibit ZNF493 by targeting the kinases that phosphorylate it, thereby preventing its activation and subsequent function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor and could inhibit ZNF493 by disrupting the PI3K/AKT signaling pathway, which may be crucial for the post-translational modification or localization of ZNF493. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which in turn inhibits ERK/MAPK pathway. By inhibiting this pathway, PD98059 can reduce the phosphorylation of substrates involved in the pathway, possibly including ZNF493, thereby inhibiting its function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the PI3K/AKT/mTOR pathway, a common signaling pathway that can regulate protein synthesis. Inhibition of this pathway can lead to functional inhibition of proteins regulated by it, including ZNF493. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP Kinase. By inhibiting p38 MAPK, SB203580 can hinder the signaling pathway that might be involved in activating ZNF493 or facilitating its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a specific inhibitor of MEK1/2, leading to downstream inhibition of the ERK/MAPK pathway. This inhibition can prevent the functional activation of proteins involved in this pathway, potentially including ZNF493. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. Inhibition of this kinase disrupts the PI3K/AKT pathway which can be critical for the phosphorylation and activation of proteins such as ZNF493. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK, which could inhibit the functional activity of ZNF493 by blocking JNK signaling pathways that may participate in ZNF493 functional regulation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, and by inhibiting ROCK, it could prevent the downstream signaling required for the proper function of ZNF493 in processes like cell shape and motility. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR inhibitor. EGFR is upstream of several signaling pathways, including those that might regulate ZNF493. Inhibition of EGFR could lead to a decrease in the functional activity of ZNF493. | ||||||