ZNF234 Inhibitors
Chemical inhibitors of ZNF234 can interact with various signaling pathways and kinases to modulate the activity of this protein. Chelerythrine and LY294002 are two such inhibitors that target different molecular pathways to achieve inhibition. Chelerythrine acts by suppressing the activity of protein kinase C (PKC), a kinase that can be pivotal for the phosphorylation and subsequent activity of ZNF234. By preventing PKC-mediated phosphorylation, this chemical effectively reduces the functional prowess of ZNF234. LY294002, on the other hand, targets the phosphoinositide 3-kinases (PI3K). This inhibition leads to a cascading effect, ultimately resulting in decreased Akt phosphorylation. Akt is a serine/threonine-specific protein kinase that regulates various cellular processes, and its diminished activity due to PI3K inhibition by LY294002 can suppress the functional activation of ZNF234.
In addition to these, PD98059 and U0126 are compounds that inhibit MEK, which is part of the MAPK signaling pathway. This particular pathway is crucial for various cellular functions, and the inhibition of MEK by these chemicals can lead to a reduction in ERK activity. Since ZNF234 may rely on ERK-mediated signaling for its activity, the inhibition by PD98059 and U0126 can attenuate the function of ZNF234. Similarly, SB203580 and SP600125 inhibit the p38 MAPK and JNK pathways, respectively. Both p38 MAPK and JNK are integral in transmitting cellular signals that could be necessary for the functional activity of ZNF234. Through the inhibition of these pathways, SB203580 and SP600125 can impede the activation or stability of ZNF234. Rapamycin, an inhibitor of the mTOR pathway, can also suppress the activity of ZNF234 by affecting key cellular growth and protein synthesis processes that ZNF234 might depend on. PP2 and Y-27632 target the Src family kinases and ROCK kinase, respectively, which may influence various signaling pathways and the cytoskeleton associated with ZNF234 activity. PD173074 and SU5402, both inhibitors of FGF receptor tyrosine kinases, can disrupt the signaling pathways that regulate ZNF234, leading to its functional suppression. Lastly, Wortmannin, akin to LY294002, inhibits the PI3K/Akt pathway, further contributing to the multiple avenues through which the activity of ZNF234 can be controlled by various chemical inhibitors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC). ZNF234 may require PKC-mediated phosphorylation for its functional activity; thus, by inhibiting PKC, chelerythrine can inhibit the phosphorylation and subsequent activity of ZNF234. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). Inhibition of PI3K can lead to a decrease in Akt phosphorylation, a kinase that may regulate the activity of ZNF234. Consequently, by inhibiting the PI3K/Akt pathway, LY294002 can functionally inhibit ZNF234. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK, which is upstream of ERK in the MAPK signaling pathway. ZNF234's function could require ERK-mediated signaling for its activation or stability, so inhibition of MEK by PD98059 can lead to a decrease in ERK activity and thus functional inhibition of ZNF234. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor, like PD98059, and it functions to block the activation of ERK. Since ZNF234 may utilize ERK signaling for its functionality, U0126 can inhibit the activation of ZNF234 by impeding the necessary upstream MEK-ERK signaling cascade. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. If ZNF234 requires p38 MAPK-mediated signaling for its functional activity, then SB203580 can inhibit the activation or stability of ZNF234 by blocking this specific MAPK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of the JNK signaling pathway. ZNF234 may depend on JNK-mediated phosphorylation events for its functional activity. Inhibition of JNK by SP600125 can therefore inhibit the functional activity of ZNF234 by preventing necessary phosphorylation events. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in cell growth and protein synthesis. ZNF234 may require mTOR-mediated signaling for its function; thus, rapamycin can inhibit the functional activity of ZNF234 by inhibiting this pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases. These kinases can phosphorylate a range of substrates and could be involved in signaling pathways that regulate ZNF234. By inhibiting Src kinases, PP2 can inhibit the functional activity of ZNF234. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK kinase, which affects the actin cytoskeleton. The cytoskeleton is integral to the positioning and function of various proteins, including ZNF234, so inhibition of ROCK by Y-27632 can lead to the functional suppression of ZNF234 activity. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is an inhibitor of the FGF receptor tyrosine kinases. These receptors are part of signaling pathways that may regulate the activity of ZNF234. By inhibiting FGF receptors, PD173074 can inhibit the functional activity of ZNF234. | ||||||