ZNF213 Inhibitors
Compounds such as MG132, Bortezomib, Epoxomicin, and Lactacystin interfere with the ubiquitin-proteasome system, an essential pathway for protein degradation. By modulating the degradation processes, these inhibitors can lead to the accumulation of proteins that directly or indirectly interact with ZNF598, potentially altering its role in ribosome-associated quality control and nonsense-mediated mRNA decay.
Translation inhibitors like Cycloheximide, Puromycin, and Emetine directly engage with the translation machinery, a key area of ZNF598's activity. These compounds can prevent the proper functioning of the ribosome, which is closely monitored by ZNF598. In doing so, they may inadvertently impact ZNF598's ability to regulate the quality of protein synthesis. Similarly, mTOR signaling is crucial for ribosomal biogenesis and protein synthesis, and its inhibition by Rapamycin can lead to changes in the cellular environment that influence ZNF598's activity. Furthermore, Actinomycin D and α-Amanitin exert their effects by disrupting RNA synthesis, which can lead to changes in the levels of RNA substrates available for ZNF598 to act upon. Chloroquine's impact on autophagy and lysosomal degradation also can modulate protein turnover, affecting ZNF598 activity indirectly. Leptomycin B's inhibition of RNA export can influence the nuclear roles of ZNF598, potentially impacting its regulatory functions.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that can prevent the degradation of ubiquitinated proteins, potentially leading to stabilization of proteins that interact with ZNF598, thus affecting its function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, potentially affecting ZNF598's role in ribosome-associated quality control. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and inhibits RNA synthesis, which can affect the RNA binding and regulatory functions of ZNF598. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Causes premature chain termination during translation by acting as an analog of the 3'-end of tyrosyl-tRNA, possibly affecting the ribosome-associated functions of ZNF598. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Inhibits autophagy and lysosomal activity, which can modulate the turnover of cellular components, including those involved in pathways where ZNF598 is active. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor that can affect protein degradation pathways and potentially interfere with the degradation of proteins that regulate ZNF598 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can affect the translation of proteins and may influence the cellular pathways that ZNF598 is involved in. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A selective proteasome inhibitor that can affect the ubiquitin-proteasome system, potentially altering the stability of ZNF598 or its interacting partners. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Inhibits the export of RNA molecules from the nucleus, potentially affecting the nuclear functions of ZNF598. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $352.00 $566.00 $1331.00 $2453.00 | ||
Protein synthesis inhibitor that can block peptide elongation, potentially affecting the ribosome-associated quality control processes involving ZNF598. | ||||||