ZN-16 Inhibitors
ZN-16 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of the ZN-16 protein, a hypothetical or less-characterized protein that might be involved in various cellular processes. The "ZN" prefix suggests a potential association with zinc finger domains, which are commonly involved in DNA binding, transcriptional regulation, or protein-protein interactions. Proteins containing zinc finger domains often play critical roles in gene expression and cellular signaling pathways. However, the exact function of ZN-16, like other members of the zinc finger protein family, may vary and could be related to regulatory activities within the cell nucleus or other compartments. Inhibitors of ZN-16 are developed to interfere with its presumed activity, providing a tool to explore the specific roles this protein might play in cellular functions.
The development of ZN-16 inhibitors involves a rigorous approach that begins with structural and functional characterization of the ZN-16 protein. Techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy are employed to elucidate the three-dimensional structure of ZN-16, particularly focusing on identifying the zinc finger domains or other critical regions that might be involved in binding to DNA, RNA, or other proteins. Understanding the structural configuration is essential for identifying potential binding sites where inhibitors can interact with ZN-16 to block its activity. Computational methods, including molecular docking and virtual screening, are then utilized to identify small molecules that can specifically bind to these sites with high affinity. Once potential inhibitors are identified, they are synthesized and subjected to in vitro testing to assess their binding affinity, specificity, and inhibitory potency. Through iterative optimization, these inhibitors are refined to improve their effectiveness and stability. The study of ZN-16 inhibitors provides valuable insights into the molecular mechanisms of zinc finger proteins and contributes to a broader understanding of their role in regulating cellular processes, gene expression, and protein interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including those that phosphorylate ZN-16, thus inhibiting its activity. By disrupting the phosphorylation process, the functional state of ZN-16 is directly affected, leading to its inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. The MAPK pathway is involved in the regulation of various transcription factors, including ZN-16. Inhibition of MEK by U0126 would prevent the phosphorylation and activation of ERK, thus preventing any downstream effects on ZN-16 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which is part of the PI3K/Akt pathway that can regulate transcription factors like ZN-16. By inhibiting PI3K, LY294002 would prevent the activation of Akt, which in turn would inhibit the phosphorylation and activity of proteins that are regulated by this pathway, including ZN-16. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key component in the PI3K/Akt pathway, which has downstream effects on various cellular processes including those that regulate transcription factors. By inhibiting mTOR, Rapamycin would disrupt the necessary signaling for ZN-16 activity, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. The p38 MAPK pathway is involved in the stress response and can modulate the activity of transcription factors. By inhibiting p38, SB203580 would prevent the phosphorylation of downstream targets, thereby inhibiting the functional activity of ZN-16. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 specifically inhibits MEK, which is essential for the activation of the ERK pathway. As the ERK pathway regulates transcription factors, inhibiting MEK with PD98059 would lead to the downregulation of the ERK pathway, thereby inhibiting the functional activity of ZN-16 which is regulated by this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, acting similarly to LY294002. By inhibiting PI3K, Wortmannin would prevent the downstream signaling required for full activation of ZN-16, leading to its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK pathway. Inhibition of JNK by SP600125 would disrupt the signaling cascade that leads to activation of transcription factors, including ZN-16. This would result in the functional inhibition of ZN-16 due to the lack of necessary phosphorylation events. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases can phosphorylate a variety of proteins, including transcription factors. By inhibiting Src kinases, PP2 can prevent the phosphorylation and subsequent activation of ZN-16, leading to its functional inhibition. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is an inhibitor of the FGFR tyrosine kinase, which could play a role in signal transduction pathways involving transcription factors like ZN-16. The inhibition of FGFR would lead to the suppression of downstream signaling necessary for the functional activity of ZN-16, thus inhibiting it. | ||||||