ZHX2 Activators
ZHX2 Activators are specialized chemical compounds that amplify the functional activity of ZHX2 through distinct signaling pathways and transcriptional regulation mechanisms. Forskolin facilitates the activation of protein kinase A (PKA) by increasing intracellular cAMP levels, which in turn can phosphorylate transcription factors that enhance ZHX2's transcriptional activity. Similarly, Retinoic Acid, by binding to its nuclear receptors, can modulate the transcriptional landscape within a cell, potentially upregulating ZHX2 expression. PMA's activation of protein kinase C (PKC) could lead to phosphorylation events that stabilize and activate ZHX2, while 5-Azacytidine and Epigallocatechin Gallate (EGCG) reduce DNA methylation, which might result in the upregulation of ZHX2 expression. Sodium Butyrate, by inhibiting histone deacetylases, promotes a transcriptionally active chromatin state that can lead to enhanced expression of the ZHX2 gene.
Furthermore, Resveratrol activates SIRT1, influencing the deacetylation of factors involved in ZHX2 regulation, while Zinc Pyrithione increases intracellular zinc levels that can act as a cofactor for ZHX2-regulating transcription factors. Lithium Chloride's inhibition of GSK-3 can stabilize transcription factors that upregulate ZHX2 expression, thus amplifying its activity. Sodium Selenite's contribution to maintaining cellular redox balance can indirectly influence the transcription factors governing ZHX2 expression. Lastly, Curcumin, by inhibiting NF-κB, may alleviate repression of ZHX2, leading to its functional enhancement. Together, these compounds act on diverse but interconnected biochemical pathways to elevate the activity of ZHX2 without necessitating changes in its direct activation or expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various transcription factors that may enhance the transcriptional activity of ZHX2 by promoting its dimerization and subsequent binding to target DNA sequences. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid binds to retinoic acid receptors (RARs), which then regulate gene expression by acting as transcription factors. Through the activation of RARs, Retinoic Acid can modulate the transcriptional network in a cell, potentially increasing the expression and activity of ZHX2 by influencing genes that control the cellular concentration of ZHX2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is involved in a variety of cellular signaling pathways. Activation of PKC can lead to phosphorylation events that enhance the stability and functional activation of ZHX2, promoting its role in transcriptional regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that leads to hypomethylation of DNA. This can result in the reactivation of genes that may be silenced by hypermethylation. Hypomethylation of the ZHX2 promoter region could enhance ZHX2 expression, thereby indirectly increasing the functional activity of ZHX2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate acts as an HDAC inhibitor similar to TSA. By inhibiting HDAC activity, it leads to histone hyperacetylation, which can activate transcription. This mechanism can induce the expression of ZHX2, leading to increased protein levels and functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol found in green tea with multiple biological effects, including the inhibition of DNA methyltransferases. This inhibition can result in reduced methylation of the ZHX2 gene promoter, potentially leading to increased expression and activation of ZHX2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate sirtuin 1 (SIRT1), a protein deacetylase. Through the activation of SIRT1, it may influence the deacetylation of transcription factors and cofactors involved in the regulation of ZHX2 expression, leading to an increase in ZHX2 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione can increase intracellular zinc levels, which may act as a cofactor for transcription factors that enhance the expression of ZHX2. Elevated intracellular zinc can influence DNA-binding affinity and transcriptional activity, potentially leading to increased ZHX2 function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits glycogen synthase kinase-3 (GSK-3), which is involved in various cellular processes including transcription regulation. By inhibiting GSK-3, Lithium Chloride may stabilize transcription factors that positively regulate ZHX2 expression, thus enhancing ZHX2 activity. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $48.00 $179.00 $310.00 $96.00 | 3 | |
Sodium Selenite can enhance the activity of antioxidant enzymes, which can influence the cellular redox state. A balanced redox state is crucial for the proper functioning of transcription factors that regulate ZHX2 expression. Therefore, by maintaining the redox balance, Sodium Selenite may contribute to the enhanced functional activity of ZHX2. | ||||||