ZFR Inhibitors
ZFR inhibitors belong to a chemical class of compounds that target the Zinc Finger RNA-binding protein (ZFR). ZFR is an evolutionarily conserved protein involved in RNA processing and post-transcriptional gene regulation. It contains zinc finger motifs, which allow it to bind to specific RNA sequences, thereby modulating RNA stability, splicing, and translation. By inhibiting ZFR's activity, these inhibitors can potentially disrupt its interactions with target RNAs and alter the post-transcriptional regulation of gene expression. This may lead to changes in RNA processing and translation efficiency, affecting various cellular processes and signaling pathways.
The study of ZFR inhibitors provides valuable insights into the complex mechanisms governing RNA metabolism and gene expression regulation. Understanding how ZFR contributes to RNA processing and function can help unravel the intricacies of cellular pathways and their relevance to development, disease, and other biological processes. However, it is essential to note that the specific applications and potential implications of ZFR inhibitors are still under investigation, and further research is required to elucidate their precise roles in cellular biology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is a compound that was initially developed as a potent inhibitor of myosin light chain kinase (MLCK), but it has also been reported to inhibit ZFR. | ||||||
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide | 120615-25-0 | sc-207901 | 10 mg | $380.00 | ||
Also called CKI-7, this compound is a casein kinase 1 (CK1) inhibitor that has been reported to inhibit ZFR. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a naturally occurring alkaloid that is a potent inhibitor of multiple kinases, including protein kinase C (PKC) and other protein kinases. It has been reported to inhibit ZFR. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a selective inhibitor of c-Raf kinase, which is part of the MAPK signaling pathway. It has also been shown to inhibit ZFR. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a semisynthetic flavone derivative that is a broad-spectrum cyclin-dependent kinase (CDK) inhibitor. It has been reported to inhibit ZFR as well. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Ellipticine is an alkaloid that exhibits anticancer properties by interfering with DNA and RNA metabolism. It has also been reported to inhibit ZFR. | ||||||
TEMPOL | 2226-96-2 | sc-200825 | 1 g | $38.00 | 33 | |
Tempol is a redox-active compound that acts as a superoxide dismutase (SOD) mimetic and has shown inhibitory effects on ZFR. | ||||||
RN 1 dihydrochloride | 1781835-13-9 | sc-397054 | 10 mg | $205.00 | ||
RN-1 is a small molecule that was identified as an inhibitor of RNA-binding proteins and has been reported to inhibit ZFR. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $186.00 $674.00 | 10 | |
Chetomin is a natural product that inhibits the activity of certain transcription factors, and it has also been shown to inhibit ZFR. | ||||||