Ythdc1 Inhibitors
Ythdc1 inhibitors are chemical compounds that specifically target and inhibit the YTH domain-containing protein 1 (Ythdc1), a crucial RNA-binding protein involved in the regulation of RNA metabolism. Ythdc1 is part of the YTH domain family, known for its role in recognizing and binding to N6-methyladenosine (m6A), a common post-transcriptional modification in eukaryotic mRNA. This protein is primarily located in the nucleus, where it plays an important role in processes such as mRNA splicing, export, and degradation. By interacting with m6A-modified RNA, Ythdc1 contributes to the regulation of RNA stability and the fine-tuning of gene expression, making it a key player in maintaining cellular function through the control of RNA fate.
Inhibitors of Ythdc1 are designed to disrupt the ability of this protein to bind to m6A-modified RNA, thereby altering its role in post-transcriptional gene regulation. These compounds interfere with the recognition or binding mechanism of Ythdc1, leading to changes in RNA processing pathways. Since Ythdc1 is involved in modulating alternative splicing, mRNA export from the nucleus, and the stability of various RNA species, inhibiting its function can have significant consequences on cellular RNA dynamics. This disruption can result in widespread effects on gene expression, particularly in genes that rely heavily on m6A modification for proper processing and expression. Understanding the structural properties of Ythdc1 inhibitors and their binding affinity is crucial for designing specific compounds that selectively target this protein without affecting other RNA-binding proteins in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been reported to inhibit the expression of YTHDC1 by interfering with the m6A-modified RNA recognition process, thereby reducing the binding affinity of YTHDC1 to its target RNAs. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine has been shown to inhibit YTHDC1 expression by modulating the m6A methylation levels, leading to reduced binding of YTHDC1 to its target m6A-modified RNAs, thus affecting its regulatory functions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been suggested to inhibit the expression of YTHDC1 by interfering with m6A methylation, leading to altered binding of YTHDC1 to m6A-modified RNAs, thereby affecting mRNA processing and splicing. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate has been found to inhibit YTHDC1 expression by interfering with m6A-modified RNA recognition, leading to disrupted binding of YTHDC1 to its target RNAs, affecting its regulatory role. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin has been reported to inhibit the expression of YTHDC1 by affecting m6A methylation, resulting in altered binding of YTHDC1 to its target m6A-modified RNAs, thus impacting mRNA processing and splicing. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein has been shown to inhibit YTHDC1 expression by interfering with the recognition of m6A-modified RNA, leading to reduced binding of YTHDC1 to its target RNAs, thereby affecting its regulatory functions. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine has been suggested to inhibit YTHDC1 expression by modulating m6A methylation levels, leading to reduced binding of YTHDC1 to its target m6A-modified RNAs, thus affecting its regulatory functions. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
Emodin has been found to inhibit YTHDC1 expression by interfering with m6A-modified RNA recognition, leading to disrupted binding of YTHDC1 to its target RNAs, affecting its regulatory role. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin has been reported to inhibit the expression of YTHDC1 by affecting m6A methylation, resulting in altered binding of YTHDC1 to its target m6A-modified RNAs, thus impacting mRNA processing and splicing. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein has been shown to inhibit YTHDC1 expression by interfering with the recognition of m6A-modified RNA, leading to reduced binding of YTHDC1 to its target RNAs, thereby affecting its regulatory functions. | ||||||