YME1L1 Activators
YME1L1 Activators are a series of chemical compounds that indirectly enhance the functional activity of YME1L1 by modulating various aspects of mitochondrial dynamics and quality control. Compounds like ADP and NAD+ are pivotal for mitochondrial energy metabolism. ADP, by serving as a substrate for ATP synthase, can indirectly stimulate YME1L1 activity by increasing the demand for mitochondrial quality control to support enhanced ATP production. Similarly, by boosting cellular NAD+ levels, Nicotinamide mononucleotide (NMN) and NAD+ enhance mitochondrial function, thereby potentially increasing the requirement for the proteolytic activity of YME1L1 to maintain mitochondrial health. Coenzyme Q10 and α-Lipoic acid, by improving electron transport and providing antioxidant support, respectively, contribute to an environment that necessitates the activation of YME1L1 to preserve mitochondrial integrity.
In concert with these, activators like SRT1720 and Resveratrol stimulate SIRT1, promoting mitochondrial biogenesis and function, which could indirectly heighten the activity of YME1L1 as part of the quality control network. BGP-15 contributes to this network by inducing heat shock proteins, which may require the upregulation of YME1L1 activity to counteract mitochondrial stress. SS-31 (Elamipretide) enhances mitochondrial membrane stabilization, indirectly necessitating the proteolytic activity of YME1L1 in maintaining mitochondrial quality. Finally, Metformin, through the activation of AMPK, leads to improved mitochondrial turnover, which could enhance the functional activity of YME1L1 by stimulating the mitochondrial quality control processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $77.00 $180.00 $312.00 $924.00 $4596.00 $9186.00 | 1 | |
ADP (Adenosine diphosphate) serves as a direct substrate for ATP synthase in mitochondria, and the increased availability of ADP can stimulate ATP production. Enhanced ATP synthesis demands more efficient mitochondrial quality control, indirectly activating YME1L1, which helps to maintain mitochondrial integrity by degrading misfolded proteins. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
Nicotinamide adenine dinucleotide (NAD+) is essential for mitochondrial energy metabolism. Augmenting cellular NAD+ levels can improve mitochondrial function and biogenesis, indirectly stimulating YME1L1 as part of a compensatory response to increased mitochondrial mass and the quality control demands associated with it. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $193.00 $357.00 | 13 | |
SRT1720 is an activator of SIRT1, a protein deacetylase that promotes mitochondrial biogenesis. Activation of SIRT1 by SRT1720 can enhance mitochondrial function and may indirectly upregulate the activity of YME1L1 as part of the mitochondrial quality control network. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, leading to improved mitochondrial function and potentially inducing a requirement for heightened mitochondrial quality control, thereby indirectly enhancing the activity of YME1L1. | ||||||
BGP-15 | 66611-37-8 | sc-507452 | 10 mg | $375.00 | ||
BGP-15 is a co-inducer of heat shock proteins and has been shown to protect against mitochondrial dysfunction. It may indirectly enhance the functional activity of YME1L1 by increasing the need for mitochondrial quality control mechanisms when mitigating heat shock protein-related stress. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is involved in the electron transport chain and is essential for mitochondrial ATP synthesis. Supplementation with Coenzyme Q10 may enhance mitochondrial function, indirectly increasing the demand for YME1L1 activity as part of mitochondrial maintenance. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic acid is an antioxidant that is known to improve mitochondrial function. By enhancing mitochondrial performance, it can indirectly stimulate the activity of YME1L1, which is involved in proteolytic quality control in the mitochondria. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN boosts levels of NAD+, which is crucial for mitochondrial energy metabolism. By enhancing the cellular NAD+ pool, NMN indirectly supports the need for YME1L1 activity due to increased mitochondrial biogenesis and function. | ||||||
Elamipretide | 736992-21-5 | sc-507453 | 25 mg | $670.00 | ||
SS-31 is a mitochondria-targeted peptide that binds to cardiolipin and stabilizes mitochondrial membranes. This action can enhance mitochondrial function and indirectly increase the activity of YME1L1 by upregulating mitochondrial quality control processes. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin activates AMP-activated protein kinase (AMPK), which can lead to improved mitochondrial biogenesis and function. Through the activation of AMPK, metformin may indirectly enhance the activity of YME1L1 by stimulating mitochondrial turnover and the associated quality control mechanisms. | ||||||