Ydj1 Inhibitors
Ydj1 inhibitors belong to a class of chemical compounds designed to target a specific cellular protein known as Ydj1. Ydj1, also referred to as Hsp40, is a crucial molecular chaperone that plays a pivotal role in the protein quality control system within cells. Its primary function is to assist in the folding and maturation of newly synthesized proteins, ensuring they attain their correct three-dimensional structures and functional conformations. Ydj1 achieves this by interacting with its client proteins, stopping their aggregation, and aiding in the proper assembly of protein complexes. Consequently, Ydj1 is essential for maintaining protein homeostasis and hindering the accumulation of misfolded or aggregated proteins, which can lead to cellular dysfunction and diseases.
Ydj1 inhibitors are designed to modulate the activity of Ydj1 by binding to specific regions of the protein, thereby interfering with its chaperone function. These inhibitors are valuable tools for researchers studying cellular protein quality control mechanisms and have applications in various areas of basic science and biotechnology. By inhibiting Ydj1, scientists can gain insights into the specific pathways and processes that rely on this chaperone protein.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $90.00 $326.00 | 13 | |
Radicicol binds to the ATP-binding domain of Hsp90, a chaperone protein that Ydj1 interacts with, thereby inhibiting its function and indirectly affecting Ydj1 activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin also targets the ATP-binding site of Hsp90, which is important for the maturation of client proteins including those associated with Ydj1. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
A derivative of geldanamycin, 17-AAG binds to the ATPase domain of Hsp90, leading to the destabilization of its client proteins, which may include those related to Ydj1 function. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $96.00 $355.00 | ||
Novobiocin is an antibiotic that also binds to the C-terminal domain of Hsp90, potentially disrupting its cooperation with Ydj1. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $54.00 $112.00 $202.00 $700.00 | 6 | |
Silybin is known to inhibit Hsp90, which may lead to a decrease in the functional activity of Ydj1 as a co-chaperone. | ||||||
NVP-AUY922 | 747412-49-3 | sc-364551 sc-364551A sc-364551B sc-364551C sc-364551D sc-364551E | 5 mg 25 mg 100 mg 250 mg 1 g 5 g | $150.00 $263.00 $726.00 $1400.00 $2900.00 $11000.00 | 3 | |
AUY-922 is an isoxazole derivative that binds to the ATP-binding domain of Hsp90, thus indirectly affecting the activity of Ydj1. | ||||||
BIIB 021 | 848695-25-0 | sc-364434 sc-364434A | 5 mg 25 mg | $128.00 $650.00 | ||
BIIB021 directly inhibits Hsp90, which may result in reduced function of Ydj1 due to its reliance on Hsp90's chaperone activity. | ||||||
CCT 018159 | 171009-07-7 | sc-202526 | 5 mg | $91.00 | ||
CCT018159 is a small molecule that inhibits Hsp90 and can therefore indirectly influence Ydj1 activity. | ||||||
Ganetespib | 888216-25-9 | sc-364496 sc-364496A | 10 mg 250 mg | $268.00 $1020.00 | ||
STA-9090 is a potent Hsp90 inhibitor that binds to its ATP-binding domain, which in turn can affect Ydj1 function. | ||||||