Ydj1 Activators
Ydj1 activators belong to a specialized chemical class known for their role in cellular stress responses and protein quality control mechanisms. These compounds are molecular chaperones that play a critical role in assisting the correct folding of proteins within the cell. The Ydj1 activators, as their name suggests, specifically target the Ydj1 protein, which is a member of the Hsp40 family of heat shock proteins. Ydj1, in turn, collaborates with the more well-known heat shock protein Hsp70, forming a complex that facilitates the folding of nascent polypeptides, refolding of misfolded proteins, and the disaggregation of protein aggregates. This collaborative effort is essential for maintaining protein homeostasis and stopping the accumulation of misfolded or damaged proteins, which can lead to cellular dysfunction and disease.
The Ydj1 activators act as enhancers of Ydj1's chaperone function. They promote the binding of Ydj1 to client proteins, thereby assisting in their proper folding and hindering their aggregation. This is particularly crucial during times of cellular stress when protein misfolding is more likely to occur. Additionally, Ydj1 activators have been found to modulate the ATPase activity of Hsp70, further fine-tuning the protein-folding process. Understanding the mechanisms and structures of Ydj1 activators can provide valuable insights into the fundamental biology of protein folding and quality control within cells.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide induces the heat shock response, which includes the upregulation of molecular chaperones. This response can lead to the enhancement of Ydj1 activity, as the protein is part of the cellular protective mechanism against stress. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol is a quinone methide triterpenoid that induces the heat shock response, leading to increased expression of heat shock proteins including Hsp70 and its co-chaperones like Ydj1, thereby enhancing Ydj1 function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can cause accumulation of misfolded proteins, enhancing the cellular need for chaperones. This can indirectly lead to increased Ydj1 activity, as it works in conjunction with Hsp70 to prevent aggregation of misfolded proteins. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A is a vacuolar-type H+-ATPase (V-ATPase) inhibitor, which can cause cellular stress and potentially enhance the expression of chaperones like Ydj1 as part of the stress response to maintain protein homeostasis. | ||||||
Zerumbone | 471-05-6 | sc-364148 sc-364148A | 10 mg 50 mg | $112.00 $408.00 | ||
Zerumbone is known to activate the heat shock response, which can lead to the induction of molecular chaperones. This could result in the enhancement of Ydj1 activity due to its role in assisting protein refolding and stabilization. | ||||||
Triton X-100 | 9002-93-1 | sc-29112 sc-29112A | 100 ml 500 ml | $20.00 $42.00 | 55 | |
Triton X-100, a nonionic surfactant, can cause protein misfolding and aggregation. This may lead to an increased chaperone requirement, indirectly enhancing the activity of Ydj1 as it aids in refolding and preventing aggregation of misfolded proteins | ||||||