Date published: 2026-4-13

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XBP-1 Antibodies

Santa Cruz Biotechnology delivers a wide array of XBP-1 monoclonal antibodies for advanced research in cellular stress responses and the unfolded protein response (UPR). XBP-1 monoclonal antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). XBP-1, or X-box binding protein 1, plays a central role in regulating gene expression during the UPR, which maintains cellular homeostasis under stress conditions. XBP-1 has significant implications in cancer and neurodegeneration, where UPR dysregulation is commonly observed. Research focused on XBP-1 can reveal potential therapeutic strategies for modulating the UPR in various pathological conditions. Understanding XBP-1's molecular mechanisms provides valuable insights into cellular stress management and disease progression. Investigating XBP-1's role in different cellular pathways helps advance our knowledge of stress-related cellular responses. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific understanding of cellular stress responses and their impact on human health.

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XBP-1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

XBP1 Antibody (F-4)

sc-8015mouse IgG1 κ76-263 (m)WB, IP, IF, ELISAm, r, h
62
(27)

XBP-1 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

XBP1 CRISPR/Cas9 KO Plasmid (h2)

sc-400131-KO-2hGene KnockoutGFP0
(0)

XBP1 HDR Plasmid (h2)

sc-400131-HDR-2hHomology Directed RepairPuromycin0
(0)

XBP1 Double Nickase Plasmid (h)

sc-400131-NIChGene KnockoutPuromycin0
(0)

XBP1 Double Nickase Plasmid (h2)

sc-400131-NIC-2hGene KnockoutPuromycin0
(0)

XBP1 CRISPR/Cas9 KO Plasmid (m)

sc-423727mGene KnockoutGFP0
(2)

XBP1 HDR Plasmid (m)

sc-423727-HDRmHomology Directed RepairPuromycin0
(2)

XBP1 Double Nickase Plasmid (m)

sc-423727-NICmGene KnockoutPuromycin0
(2)

XBP1 Double Nickase Plasmid (m2)

sc-423727-NIC-2mGene KnockoutPuromycin0
(2)

XBP-1 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

XBP1 CRISPR Activation Plasmid (h)

sc-400131-ACThGene ActivationPuro, Blast, Hygro0
(0)

XBP1 CRISPR Activation Plasmid (m)

sc-423727-ACTmGene ActivationPuro, Blast, Hygro0
(2)

XBP1 CRISPR Activation Plasmid (m2)

sc-423727-ACT-2mGene ActivationPuro, Blast, Hygro0
(2)

XBP1 Lentiviral Activation Particles (m)

sc-423727-LACmGene ActivationPuro, Blast, Hygro0
(2)

XBP-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

XBP1 siRNA (h)

sc-38627hGene SilencingN/A
35
(1)

XBP1 shRNA Plasmid (h)

sc-38627-SHhGene SilencingPuromycin
35
(1)

XBP1 shRNA (h) Lentiviral Particles

sc-38627-VhGene SilencingPuromycin
35
(1)

XBP1 siRNA (m)

sc-38628mGene SilencingN/A
9
(0)

XBP1 shRNA Plasmid (m)

sc-38628-SHmGene SilencingPuromycin
9
(0)

XBP1 shRNA (m) Lentiviral Particles

sc-38628-VmGene SilencingPuromycin
9
(0)