XAB1 Activators
XAB1, also known as G-patch domain-containing protein 1 (GPATCH1), is a human protein implicated in the intricate process of mRNA splicing. This protein is part of the spliceosome, a complex and dynamic assembly of snRNPs (small nuclear ribonucleoproteins) and a multitude of associated proteins, which orchestrates the removal of non-coding sequences (introns) from pre-mRNA transcripts. The accurate and efficient splicing of pre-mRNA is essential for the generation of functional messenger RNAs that direct the synthesis of proteins.The G-patch domain is a characteristic feature of XAB1, which suggests a role in RNA processing. This domain is known for its involvement in RNA binding, indicating that XAB1 may directly interact with RNA or other components of the spliceosome during the splicing process. The precise molecular functions of XAB1, however, are not fully understood and are the subject of ongoing research.
Alterations in the splicing machinery, including dysfunctions associated with proteins like XAB1, can lead to aberrant splicing events. Such splicing errors are linked to a variety of diseases, including cancer and genetic disorders, highlighting the importance of proteins involved in this fundamental cellular process.As a spliceosomal protein, XAB1 is likely to be involved in the regulation of splicing under various physiological conditions, and its activity may be modulated in response to cellular signals and stressors, reflecting the dynamic nature of gene regulation at the level of RNA processing.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
It can modulate gene expression and might influence the expression of genes involved in RNA processing. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, it can alter chromatin structure and potentially increase XAB1 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Another histone deacetylase inhibitor that can lead to changes in gene expression, possibly affecting XAB1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
It raises intracellular cAMP levels, which may alter transcription factor activity and gene expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress and could affect the expression of a variety of genes, including those involved in RNA splicing. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A known inducer of ER stress, which can lead to a general upregulation of stress response genes. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
It induces DNA damage response and could potentially affect the expression of DNA repair and RNA splicing genes. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
A heavy metal that induces cellular stress, potentially affecting the expression of various genes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences GSK-3 activity and Wnt signaling, which might indirectly affect gene expression. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Known to cause oxidative stress and may alter the expression of numerous genes, including those in RNA splicing. | ||||||