Wnt-6 Activators
Wnt-6 activators belong to a distinct chemical class within the realm of molecular biology and developmental biology. These compounds play a pivotal role in the intricate Wnt signaling pathway, which is a fundamental and highly conserved molecular cascade that regulates various cellular processes during embryonic development, tissue homeostasis, and adult organism maintenance. The Wnt signaling pathway encompasses a family of secreted glycoproteins known as Wnts, and Wnt-6 is one of its specific members. Activators of Wnt-6 are molecules or compounds that facilitate the initiation or augmentation of Wnt-6 signaling, thereby influencing cellular responses.
Wnt-6 activators typically interact with key components of the Wnt signaling pathway, such as the Frizzled family of receptors and LRP co-receptors, to initiate a cascade of intracellular events. This cascade ultimately leads to the stabilization and nuclear translocation of β-catenin, a critical transcriptional co-activator. In the absence of Wnt signaling, β-catenin is continually degraded. However, upon activation by Wnt-6 or its activators, β-catenin accumulates in the cytoplasm and translocates into the nucleus, where it forms complexes with T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors. This nuclear complex subsequently regulates the expression of various target genes, orchestrating a diverse array of cellular processes, including cell fate determination, proliferation, migration, and tissue morphogenesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, leading to the stabilization and accumulation of β-catenin in the cytoplasm. Accumulated β-catenin then translocates into the nucleus and activates Wnt/β-catenin target genes, including Wnt-6, enhancing its signaling functions in processes such as embryogenesis and cell differentiation. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 Inhibitor IX, BIO, is a specific inhibitor of GSK-3. By inhibiting GSK-3, BIO prevents the phosphorylation and degradation of β-catenin, thus facilitating the activation of Wnt/β-catenin signaling. This enhances the activity of Wnt-6 by promoting the accumulation of β-catenin, which can act as a co-factor in the transcriptional activation of Wnt-6 target genes. | ||||||
SKL2001 | 909089-13-0 | sc-507410 | 10 mg | $123.00 | ||
SKL2001 acts as an agonist for the Wnt/β-catenin signaling pathway by stabilizing the β-catenin complex, thus preventing its degradation. This enhanced signaling leads to increased activity of downstream targets such as Wnt-6, which plays a role in regulating cell proliferation and migration. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
GSK-3 Inhibitor XVI, CHIR99021, is a potent and selective GSK-3 inhibitor that leads to the accumulation and nuclear translocation of β-catenin by preventing its phosphorylation. The enhanced nuclear β-catenin can then facilitate the transcription of Wnt target genes, including Wnt-6, thus increasing its signaling activity within the Wnt/β-catenin pathway. | ||||||
Wnt Synergist, QS11 | 944328-88-5 | sc-222417 sc-222417A | 5 mg 25 mg | $141.00 $607.00 | ||
QS11 inhibits ARF-GAP, which leads to the accumulation of Wnt/beta-catenin signaling components by disrupting cellular trafficking. This accumulation can result in enhanced Wnt-6 signaling activity, as Wnt-6 is a part of the Wnt/beta-catenin pathway, which regulates cell fate determination and tissue homeostasis. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is another GSK-3 inhibitor that promotes β-catenin stabilization, enhancing the Wnt/β-catenin signaling pathway and indirectly increasing Wnt-6 activity. It does so by preventing β-catenin phosphorylation and degradation, thus allowing β-catenin to activate transcription of Wnt-6-regulated genes involved in cellular processes such as development and growth. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Pyrvinium Pamoate activates the Wnt/β-catenin signaling pathway by inhibiting CK1α, which is involved in the phosphorylation of β-catenin. This inhibition leads to reduced β-catenin degradation and increased nuclear β-catenin levels. | ||||||