Date published: 2026-4-1

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VWC2 Activators

The chemical class known as VWC2 Activators encompasses a range of compounds that can exert influence on the von Willebrand factor type C domain-containing protein 2 (VWC2) through indirect mechanisms involving various cellular signaling pathways and processes. These activators can modulate the activity of VWC2 not by binding directly to it, but by altering the cellular environment or the signaling cascades that VWC2 is a part of. The chemicals that fall under this category are often inhibitors or agonists of pathways such as BMP signaling, TGF-β signaling, integrin-mediated cell adhesion, and collagen synthesis. By intervening in these pathways, VWC2 activators can alter the downstream effects that ultimately affect the function of VWC2 within the cell.

The action of VWC2 activators is typically characterized by their ability to influence cellular processes that are either directly or indirectly related to the role of VWC2. This can include modulation of extracellular matrix organization, angiogenesis, and cell survival pathways. The changes induced by these chemicals can result in an alteration of the normal functioning of VWC2, which in turn can lead to changes in the cellular processes that VWC2 influences. It is through these nuanced and interconnected pathways that these activators can exert their effects, often involving a cascade of intracellular events that lead to the modulation of VWC2's activity. As such, the term VWC2 Activators is used to denote a broad and diverse set of compounds that share the common feature of being able to engage with and influence the function of VWC2 through indirect yet significant means within the cellular milieu.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BML-275

866405-64-3sc-200689
sc-200689A
5 mg
25 mg
$96.00
$355.00
69
(1)

Dorsomorphin inhibits BMP signaling and could possibly activate VWC2 by altering the pathway with which VWC2 interacts.

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

1062368-24-4sc-476297
5 mg
$240.00
(0)

LDN-193189 is a selective BMP signaling inhibitor that could possibly activate VWC2 by modulating the activity of proteins involved in BMP pathways.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$82.00
$216.00
$416.00
48
(1)

SB-431542 inhibits the TGF-β pathway, which could possibly activate VWC2 by impacting the BMP pathway and proteins like VWC2 that are associated with this signaling.

Thiazovivin

1226056-71-8sc-361380
sc-361380A
10 mg
25 mg
$284.00
$634.00
15
(1)

Thiazovivin is a ROCK inhibitor that promotes cell adhesion and survival, and could possibly activate VWC2 by influencing cellular interactions and ECM composition.

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$202.00
$811.00
16
(1)

A-83-01 inhibits TGF-β type I receptor ALK5, which could possibly activate VWC2 by altering TGF-β/BMP-related pathways.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$186.00
$707.00
88
(1)

Y-27632 is a ROCK inhibitor that can affect cytoskeleton dynamics and cell shape, and could possibly activate VWC2 by influencing the cellular context of its function.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Forskolin increases cAMP levels, which can activate PKA and could possibly activate VWC2 by influencing related pathways.

Puerarin

3681-99-0sc-202301
sc-202301A
5 mg
100 mg
$132.00
$209.00
1
(0)

Puerarin has been shown to stimulate the BMP pathway and promote osteoblastic differentiation, which could possibly activate VWC2 by affecting its function in this pathway.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein is a tyrosine kinase inhibitor that could possibly activate VWC2 by modulating various signaling pathways, including those that might intersect with VWC2's function.