VP16 Activators
VP16 activators belong to a class of chemical compounds that play a pivotal role in molecular biology and genetic research. These activators serve as crucial tools for studying gene expression and regulation. VP16 activators are named after the herpes simplex virus protein VP16 (Viral Protein 16), which is known for its ability to enhance transcriptional activity. This class of compounds includes synthetic transcriptional activators and peptide sequences found in VP16, designed to stimulate gene expression in a controlled and specific manner.
The primary function of VP16 activators is to amplify the transcription of target genes in various experimental settings. They work by binding to specific DNA sequences within the promoter regions of genes, recruiting transcriptional machinery, and promoting the initiation of RNA synthesis. This potent activation property has made VP16 activators invaluable in molecular biology research, allowing scientists to manipulate and study gene expression patterns. Researchers often use VP16 activators in combination with other molecular techniques to investigate gene function, regulatory mechanisms, and the impact of altered gene expression on cellular processes. By providing a means to artificially boost gene expression, VP16 activators contribute to our understanding of genetic and cellular biology, paving the way for advances in various fields such as genetics, developmental biology, and biotechnology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is another histone deacetylase inhibitor that can promote acetylation of histones, potentially facilitating the transcription of genes including VP16. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, possibly leading to demethylation of the VP16 gene promoter and enhancing its expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, a histone deacetylase inhibitor, may contribute to increased acetylation of histones and enhanced expression of genes such as VP16. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels, which can potentially induce VP16 expression through cAMP response element-binding protein (CREB) activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression through retinoic acid receptors, potentially influencing the expression of VP16. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This polyphenol found in green tea has been shown to influence gene expression and may potentially induce the expression of VP16. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, found in grapes and berries, has been shown to influence gene expression and may potentially induce VP16 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can activate the Wnt signaling pathway, potentially leading to altered gene expression and induction of VP16. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can modulate gene expression through glucocorticoid receptors, potentially influencing VP16 expression. | ||||||