Vmn1r94 Activators
Vmn1r94, a key member of the vomeronasal receptor family, is intricately involved in chemosensory detection, playing a critical role in guiding social and reproductive behaviors across various species. Located within the vomeronasal organ, Vmn1r94 functions as a molecular gatekeeper, responding to specific chemical cues and translating them into neuronal signals that influence species-specific behaviors. The activation of Vmn1r94 involves a sophisticated interplay of molecular events influenced by various chemicals acting either directly or indirectly on the receptor.
Direct activators, such as Forskolin and Retinoic Acid, directly stimulate key signaling pathways like cAMP-PKA and RARs, respectively, enhancing Vmn1r94 expression and cellular activity. Indirect activators, including Epidermal Growth Factor and 8-Br-cGMP, modulate broader pathways like MAPK and cGMP-PKG, respectively, influencing downstream targets crucial for Vmn1r94 function. This diversity in activators underscores the complexity of Vmn1r94 regulation, emphasizing the integration of various cellular pathways to modulate the functional capacity of this vomeronasal receptor. The exploration of such chemical activators not only deepens our understanding of Vmn1r94 activation but also provides valuable insights into potential strategies for manipulating chemosensory responses in the intricate tapestry of species-specific communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, acting through retinoic acid receptors (RARs), initiates transcriptional events that positively impact Vmn1r94. RAR activation induces the expression of key transcription factors related to Vmn1r94, promoting its transcriptional activity and leading to an upregulation in the overall functional capacity of the vomeronasal receptor within the organ. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP, a cell-permeable cAMP analog, directly elevates intracellular cAMP levels. This rise in cAMP activates protein kinase A (PKA), positively modulating Vmn1r94. Subsequent downstream signaling events induced by PKA activation contribute to enhanced expression and functional activity of Vmn1r94 within the vomeronasal organ. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a deacetylase, impacting the acetylation status of proteins associated with Vmn1r94. This modulation promotes the deacetylation of specific histones, facilitating an open chromatin structure conducive to increased Vmn1r94 transcription. Consequently, resveratrol serves as an indirect activator by epigenetically enhancing the gene's accessibility and promoting its functional expression within the vomeronasal organ. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cGMP, a cell-permeable cGMP analog, directly elevates intracellular cGMP levels. This increase in cGMP activates protein kinase G (PKG), positively modulating Vmn1r94. Subsequent signaling events induced by PKG activation contribute to enhanced expression and functional activity of Vmn1r94 within the vomeronasal organ. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
9-cis-retinoic acid, acting through retinoic acid receptors (RARs), initiates transcriptional events influencing Vmn1r94. RAR activation induces the expression of key transcription factors related to Vmn1r94, promoting its transcriptional activity and leading to an upregulation in the overall functional capacity of the vomeronasal receptor within the organ. | ||||||