Vmn1r170 Activators
Vmn1r170, a crucial member of the vomeronasal receptor family, orchestrates the intricate network of chemosensory responses governing social and reproductive behaviors across various species. Positioned within the vomeronasal organ, Vmn1r170 serves as a molecular sentinel, responding to specific chemical cues in the environment and translating them into neuronal signals that drive species-specific behaviors. The activation of Vmn1r170 involves a cascade of molecular events influenced by various chemicals acting either directly or indirectly on the receptor.
Direct activators, such as Forskolin and Dibutyryl cAMP, engage the cAMP-PKA signaling pathway, enhancing Vmn1r170 expression and cellular activity. Indirect activators, like Retinoic Acid and Epidermal Growth Factor, exploit pathways like retinoic acid receptor (RAR) and MAPK, respectively, impacting the transcriptional landscape related to Vmn1r170 activity. These diverse activators highlight the multifaceted nature of Vmn1r170 regulation, demonstrating the integration of various cellular pathways to modulate the functional capacity of this vomeronasal receptor. The exploration of such chemical regulators not only enriches our understanding of Vmn1r170 activation but also unveils potential strategies for modulating chemosensory responses in the intricate tapestry of species-specific communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, elevating cAMP levels. The increased cAMP activates protein kinase A (PKA), positively influencing Vmn1r170. Subsequent signaling cascades induced by PKA enhance the transcription and translation of Vmn1r170, ultimately leading to an augmentation in the functional activity of the vomeronasal receptor within the organ. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts through retinoic acid receptors (RARs), initiating transcriptional events that positively impact Vmn1r170. RAR activation induces the expression of key transcription factors related to Vmn1r170, promoting its transcriptional activity and resulting in an upregulation of the overall functional capacity of the vomeronasal receptor within the organ. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP, a cell-permeable cAMP analog, directly elevates intracellular cAMP levels. This rise in cAMP activates protein kinase A (PKA), positively modulating Vmn1r170. Subsequent downstream signaling events induced by PKA activation contribute to enhanced expression and functional activity of Vmn1r170 within the vomeronasal organ. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a deacetylase, impacting the acetylation status of proteins associated with Vmn1r170. This modulation promotes the deacetylation of specific histones, facilitating an open chromatin structure conducive to increased Vmn1r170 transcription. Consequently, resveratrol serves as an indirect activator by epigenetically enhancing the gene's accessibility and promoting its functional expression within the vomeronasal organ. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cGMP, a cell-permeable cGMP analog, directly elevates intracellular cGMP levels. This increase in cGMP activates protein kinase G (PKG), positively modulating Vmn1r170. Subsequent signaling events induced by PKG activation contribute to enhanced expression and functional activity of Vmn1r170 within the vomeronasal organ. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
9-cis-retinoic acid, acting through retinoic acid receptors (RARs), initiates transcriptional events influencing Vmn1r170. RAR activation induces the expression of key transcription factors related to Vmn1r170, promoting its transcriptional activity and leading to an upregulation in the overall functional capacity of the vomeronasal receptor within the organ. | ||||||