Vmn1r127 Inhibitors
Vmn1r127 is a vomeronasal 1 receptor that plays a role in detecting pheromones and mediating social behaviors in certain species. While direct inhibitors of Vmn1r127 are not currently known, we can consider potential indirect inhibitors based on the signaling pathways and cellular processes involved. Several potential indirect inhibitors can influence the signaling pathways associated with Vmn1r127. Tetrodotoxin can inhibit Vmn1r127 by blocking the sodium channels involved in signal transduction downstream of receptor activation. Brefeldin A can disrupt the proper trafficking and localization of Vmn1r127 to the cell surface by inhibiting protein transport. Wortmannin and LY294002 can inhibit phosphoinositide 3-kinase (PI3K), potentially disrupting downstream signaling events mediated by PI3K. Cyclopamine and rapamycin can inhibit the Hedgehog and mTOR pathways, respectively, which may affect Vmn1r127 if the receptor is involved in these pathways.
U0126 and SB203580 can inhibit key kinases in the MAPK signaling pathway, potentially disrupting downstream signaling events. H89 and staurosporine can inhibit protein kinases, including PKA and PKC, respectively, which may affectVmn1r127 if these kinases are involved in its signaling. Geldanamycin can disrupt the proper folding and stability of Vmn1r127 by inhibiting heat shock protein 90 (Hsp90), a chaperone protein. Lastly, 2-APB can potentially inhibit Vmn1r127 if the receptor is coupled to calcium signaling pathways by inhibiting inositol trisphosphate receptors (IP3Rs). Overall, Vmn1r127 inhibitors encompass a range of compounds that target various aspects of the receptor's signaling pathways and cellular processes. These inhibitors can potentially disrupt receptor activation, trafficking, downstream signaling events, and proper folding, leading to the inhibition of Vmn1r127-mediated responses to pheromones and social behaviors. Further research is needed to validate the specific involvement of these inhibitors in inhibiting Vmn1r127 and to uncover additional inhibitors that directly target the receptor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is a fungal metabolite that inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus. It can potentially inhibit Vmn1r127 by disrupting the proper trafficking and localization of the receptor to the cell surface. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a fungal metabolite that inhibits phosphoinositide 3-kinase (PI3K), a key enzyme involved in signal transduction pathways. It can potentially inhibit Vmn1r127 by disrupting downstream signaling events mediated by PI3K. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is a naturally occurring steroidal alkaloid that inhibits the Hedgehog signaling pathway. It can potentially inhibit Vmn1r127 if the receptor is involved in this pathway, leading to the disruption of downstream signaling events. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), a key kinase in the MAPK signaling pathway. It can potentially inhibit Vmn1r127 by disrupting downstream signaling events mediated by MEK. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, a key enzyme involved in signal transduction pathways. It can potentially inhibit Vmn1r127 by disrupting downstream signaling events mediated by PI3K. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB203580 is a selective inhibitor of p38 MAPK, a key kinase in the MAPK signaling pathway. It can potentially inhibit Vmn1r127 by disrupting downstream signaling events mediated by p38 MAPK. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an immunosuppressant that inhibits the mammalian target of rapamycin (mTOR) pathway. It can potentially inhibit Vmn1r127 if the receptor is involved in this pathway, leading to the disruption of downstream signaling events. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H89 is a selective inhibitor of protein kinase A (PKA), a key kinase involved in various signaling pathways. It can potentially inhibit Vmn1r127 by disrupting downstream signaling events mediated by PKA. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin is a natural product that inhibits heat shock protein 90 (Hsp90), a chaperone protein involved in protein folding and stabilization. It can potentially inhibit Vmn1r127 by disrupting the proper folding and stability of the receptor. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including protein kinase C (PKC). It can potentially inhibit Vmn1r127 by disrupting downstream signaling events mediated by PKC. | ||||||