Vmn1r127 Activators
Vmn1r127 Activators comprise a set of chemical compounds that enhance the functionality of Vmn1r127 through diverse indirect mechanisms, primarily by modulating the signaling pathways within which this vomeronasal receptor operates. Forskolin, by raising intracellular cAMP levels, indirectly augments Vmn1r127 signaling through the activation of PKA, which then phosphorylates various substrates involved in GPCR pathways, a key component of Vmn1r127's operational framework. Capsaicin and Menthol, through their respective roles as TRPV1 and TRPM8 agonists, modulate calcium influx in sensory neurons, thereby creating a conducive environment for Vmn1r127's enhanced response to pheromonal stimuli. Similarly, Icilin and Cinnamaldehyde, affecting TRP channels, alter intracellular calcium dynamics, indirectly facilitating Vmn1r127's sensory functions. Compounds like Olfactory Sulphide and Homomelatonin, by interacting with olfactory receptors and melatonin receptors respectively, set off a cascade of events in GPCR-mediated pathways, indirectly bolstering Vmn1r127's role in olfactory signaling.
The action of Zinc Sulfate is more foundational, ensuring optimal health and responsiveness of olfactory receptor neurons, thereby indirectly enhancing Vmn1r127's functional capacity. Glutamate and Histamine, through their modulation of neurotransmitter receptors, influence the neuronal circuitry connected to Vmn1r127, potentially amplifying its signaling in detecting specific pheromones. Epinephrine and Muscarine, by interacting with adrenergic and cholinergic receptors, respectively, modify the neuronal excitability and signaling landscape, impacting Vmn1r127's pheromone sensing capabilities. Collectively, these activators work through various biochemical pathways, enhancing the functionality of Vmn1r127 in a nuanced manner, focusing on the receptor's role in olfactory and pheromone sensing without directly altering its expression or direct activation mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, by elevating intracellular cAMP levels, indirectly enhances Vmn1r127 activity. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various substrates that influence G-protein coupled receptor (GPCR) pathways, indirectly augmenting Vmn1r127 signaling. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $89.00 $252.00 | 9 | |
Icilin, a cooling agent, affects transient receptor potential (TRP) channels. TRP channel modulation alters intracellular calcium levels, which can indirectly influence Vmn1r127's activity in olfactory and pheromone signaling. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, a TRPV1 agonist, affects sensory neuron signaling by modulating calcium influx. This modulation can indirectly impact Vmn1r127 activity by altering the sensory neuron environment, potentially enhancing its response to specific ligands. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Sulfate, essential for olfactory transduction, can indirectly enhance Vmn1r127's function by optimizing olfactory receptor neuron health and responsiveness, impacting GPCR-mediated signaling. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol, a TRPM8 agonist, affects sensory neurons by modulating calcium channels. This modulation can influence the signaling environment of Vmn1r127, potentially enhancing its pheromone sensing capabilities. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde, by activating TRPA1 channels, can indirectly enhance Vmn1r127 activity through alterations in calcium signaling, thereby influencing the olfactory receptor neuron environment. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate, a key neurotransmitter, influences synaptic signaling. Its action on glutamate receptors can modulate neuronal circuits connected to Vmn1r127, potentially enhancing its signaling capacity in pheromone detection. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through H1 receptor activation, can modulate neuronal signaling pathways. This modulation might indirectly influence Vmn1r127's activity by altering the sensory neuron signaling landscape, impacting its response to specific ligands. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, interacting with adrenergic receptors, can modulate neuronal excitability. This can indirectly influence Vmn1r127's activity by affecting the overall signaling environment in olfactory neurons. | ||||||