VEZF1 Inhibitors
Chemical inhibitors of VEZF1 can modulate the activity of this transcription factor through a variety of mechanisms, primarily by altering its phosphorylation state. Staurosporine acts as a broad-spectrum inhibitor of protein kinases, which can impede the phosphorylation of VEZF1, thus attenuating its ability to regulate gene transcription. LY294002 and Wortmannin target the phosphoinositide 3-kinases (PI3K) pathway, which is known to have a regulatory role on various transcription factors including VEZF1. By inhibiting PI3K, these chemicals can lead to a reduced phosphorylation of VEZF1, potentially diminishing its DNA-binding capacity and transcriptional activity. Similarly, PD98059 and U0126, both inhibitors of MEK, can decrease the phosphorylation of VEZF1 by preventing the activation of ERK, a kinase that may act upstream of VEZF1 in certain signaling cascades.
Additionally, SP600125, as an inhibitor of c-Jun N-terminal kinase (JNK), and SB203580, targeting the p38 MAP kinase, can both lead to reduced activity of VEZF1. By inhibiting these kinases, the chemicals can disrupt the normal phosphorylation-dependent modulation of VEZF1, which is crucial for its role in gene expression regulation. Another kinase, mTOR, indirectly influences transcription factors, and its inhibitor, Rapamycin, can therefore result in a decrease in VEZF1 function related to the control of cell growth and proliferation genes. PKC inhibitors such as Ro-31-8220, GF109203X, and Go6976 can reduce VEZF1's activity by altering its phosphorylation status, affecting its interaction with the transcriptional machinery. Lastly, H-89 targets protein kinase A (PKA), another kinase that can phosphorylate a range of proteins including transcription factors like VEZF1. Inhibition of PKA by H-89 can lead to decreased transcriptional regulatory function of VEZF1. Each of these chemicals can contribute to the modulation of VEZF1's role in gene expression by affecting its phosphorylation through different kinases that are part of cellular signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. VEZF1 binds to specific DNA sequences and acts as a transcription factor. Staurosporine can inhibit kinase activities that are responsible for the phosphorylation of VEZF1, which can be critical for its function. By inhibiting these kinases, staurosporine can reduce VEZF1 activity in transcriptional regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). PI3K signaling can regulate various transcription factors and may have a role in the phosphorylation state of VEZF1. Inhibition of PI3K by LY294002 can lead to decreased activity of VEZF1 by altering its phosphorylation and thereby its ability to bind DNA or interact with other transcriptional machinery. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinase (ERK). ERK can influence the transcriptional activity of various transcription factors. Inhibition of this pathway by PD98059 can lead to a reduction in VEZF1's transcriptional activity by impacting its phosphorylation state or interaction with other proteins. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor, which also prevents the activation of ERK. By inhibiting MEK, U0126 can decrease ERK-mediated phosphorylation events that could affect VEZF1's function as a transcription factor, resulting in decreased transcriptional activity of VEZF1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in regulatory processes including transcription factor modulation. Through inhibition of JNK, SP600125 can alter transcription factor dynamics that VEZF1 might be part of, leading to a reduction in VEZF1's activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which plays a role in inflammatory responses and transcription factor regulation. By inhibiting p38, SB203580 can decrease VEZF1 activity by affecting its ability to regulate gene expression, as p38 MAP kinase can influence transcription factor function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. Similar to LY294002, wortmannin can inhibit the PI3K pathway, which may be involved in the regulation of VEZF1. This inhibition can lead to reduced transcriptional activity of VEZF1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of the mammalian target of rapamycin (mTOR), which is a key regulator of cell growth and proliferation. mTOR can indirectly influence transcription factors; therefore, rapamycin's inhibition of mTOR may lead to decreased VEZF1 function in cell growth-related gene expression. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
Ro-31-8220 is a potent protein kinase C (PKC) inhibitor. Since PKC can phosphorylate various substrates including transcription factors, inhibiting PKC with Ro-31-8220 can decrease the activity of VEZF1 by affecting its phosphorylation state and subsequent DNA-binding ability. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is a selective inhibitor of PKC. By inhibiting PKC, GF109203X can lead to reduced phosphorylation and activation of transcription factors such as VEZF1, thus inhibiting its functional role in gene transcription. | ||||||