VacA Activators
VacA modulators, as listed, are primarily chemicals that indirectly affect the activity or expression of VacA by targeting Helicobacter pylori or influencing the environment in which the bacterium survives and thrives. The chemicals mentioned, such as antibiotics (Metronidazole, Clarithromycin, Amoxicillin), proton pump inhibitors, and natural compounds with antimicrobial properties (Lactoferrin, Sulforaphane, Curcumin), act on H. pylori's viability, colonization capability, and virulence factor expression.
These modulators are significant in understanding and managing H. pylori infections. By affecting the bacterium's survival or its ability to colonize the gastric mucosa, these substances can indirectly influence the pathogenic action of VacA. For example, antibiotics used in H. pylori eradication therapy can reduce the bacterial load, thereby decreasing VacA-mediated cytotoxic effects.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bismuth(III) subsalicylate | 14882-18-9 | sc-227416 | 100 g | $30.00 | ||
Bismuth Subsalicylate can disrupt H. pylori's cellular processes, potentially affecting VacA expression or activity. | ||||||
Amoxicillin | 26787-78-0 | sc-485485 | 5 g | $179.00 | 3 | |
Amoxicillin disrupts bacterial cell wall synthesis, potentially impacting H. pylori survival and hence VacA activity. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Proton pump inhibitors reduce stomach acidity, affecting H. pylori's environment and possibly its expression of VacA. | ||||||
Lactoferrin | 146897-68-9 | sc-394420 sc-394420A sc-394420B sc-394420C | 10 mg 50 mg 100 mg 1 g | $122.00 $408.00 $580.00 $1494.00 | ||
Lactoferrin has antibacterial properties and may impact H. pylori's ability to express and secrete VacA. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-acetylcysteine can disrupt biofilms and may aid in the treatment of H. pylori infections, indirectly affecting VacA. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc has antimicrobial effects and may influence H. pylori's viability and VacA expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been reported to have anti-H. pylori activity, possibly influencing VacA activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine exhibits antimicrobial activity against H. pylori, potentially impacting its ability to produce VacA. | ||||||