V2R11 Inhibitors
Chemical inhibitors of V2R11 include a variety of compounds that interact with the renin-angiotensin-aldosterone system (RAAS) at different points to inhibit the activity of this protein. Olmesartan, Losartan, Eprosartan, Telmisartan, Valsartan, Irbesartan, Candesartan, Azilsartan, and Fimasartan are all angiotensin II receptor blockers (ARBs) that directly block the angiotensin II type 1 receptor. This receptor, when activated by angiotensin II, can increase the activity of V2R11 among other effects. By preventing angiotensin II from binding to its receptor, these ARBs can reduce V2R11 activity. Aliskiren operates upstream in the RAAS by inhibiting renin, which is responsible for the conversion of angiotensinogen to angiotensin I, the precursor of angiotensin II. With less angiotensin II being formed, the activation of the angiotensin II receptor and subsequent increase in V2R11 activity is lessened.
Eplerenone and Spironolactone act at a different point in the RAAS by blocking aldosterone receptors. Aldosterone can modulate the activity of V2R11 indirectly through its effects on sodium and water retention. By antagonizing aldosterone receptors, Eplerenone and Spironolactone inhibit the action of aldosterone, leading to a decrease in V2R11 activity. All these chemical inhibitors, by blocking different components of the RAAS, contribute to the regulation of V2R11 activity. Each chemical has a unique binding affinity and selectivity for its target, which determines the extent and duration of V2R11 inhibition. Together, these inhibitors encompass a broad approach to modulating the activity of V2R11 through interference with the RAAS system.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan is another ARB that works similarly to Olmesartan by blocking the angiotensin II receptor type 1. Through this blockade, Losartan inhibits the signaling cascade initiated by angiotensin II, potentially reducing the activity of downstream proteins like V2R11 that are implicated in blood pressure homeostasis and fluid balance. | ||||||
Eprosartan | 133040-01-4 | sc-207631 | 10 mg | $169.00 | 1 | |
Eprosartan is an ARB that selectively inhibits the binding of angiotensin II to its receptor. This inhibition disrupts the angiotensin II pathway, leading to a decrease in the activity of proteins like V2R11 involved in the regulation of vasoconstriction and aldosterone secretion. | ||||||
Telmisartan | 144701-48-4 | sc-204907 sc-204907A | 50 mg 100 mg | $72.00 $94.00 | 8 | |
Telmisartan is an ARB known for its high affinity for the angiotensin II receptor. It inhibits angiotensin II-induced signaling, which could reduce the activity of V2R11 by preventing the downstream effects of angiotensin II on blood pressure and fluid balance. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $40.00 $92.00 $122.00 | 4 | |
Valsartan is an ARB that inhibits angiotensin II receptors, leading to a reduction in the action of angiotensin II. This inhibition is expected to downregulate the activity of proteins such as V2R11 that are involved in the physiological responses to angiotensin II, like blood pressure regulation and water reabsorption. | ||||||
Irbesartan | 138402-11-6 | sc-218603 sc-218603A | 10 mg 50 mg | $106.00 $303.00 | 3 | |
Irbesartan is an ARB that impedes angiotensin II from interacting with its receptor. By blocking this receptor, Irbesartan likely decreases the activity of proteins like V2R11 that are part of the angiotensin II-related regulatory mechanisms for blood pressure and fluid balance. | ||||||
Candesartan | 139481-59-7 | sc-217825 sc-217825B sc-217825A | 10 mg 100 mg 1 g | $47.00 $94.00 $151.00 | 6 | |
Candesartan is an ARB that binds to the angiotensin II receptor, inhibiting its action. This blockade may decrease the activity of V2R11 by preventing the vasoconstrictive and aldosterone-secreting effects normally stimulated by angiotensin II. | ||||||
Azilsartan | 147403-03-0 | sc-503231 sc-503231A sc-503231B sc-503231C sc-503231D sc-503231E | 10 mg 50 mg 100 mg 250 mg 500 mg 1 g | $140.00 $180.00 $230.00 $370.00 $490.00 $781.00 | ||
Azilsartan is an ARB that inhibits the effects of angiotensin II by blocking its receptor. As a result, proteins like V2R11 that are involved in the response to angiotensin II are expected to have reduced activity, impacting blood pressure and fluid regulation. | ||||||
Eplerenone | 107724-20-9 | sc-203943 sc-203943A | 10 mg 50 mg | $110.00 $624.00 | 4 | |
Eplerenone is a selective aldosterone receptor antagonist that inhibits the action of aldosterone, a hormone that can indirectly affect proteins like V2R11 through the regulation of sodium and water retention. By antagonizing aldosterone receptors, Eplerenone is expected to inhibit the activity of V2R11 linked to fluid balance and blood pressure control. | ||||||