V1RC21 Activators
Chemical activators of V1RC21 can engage with the protein through various interactions that stabilize the active conformation of the receptor, which in turn initiates a signal transduction cascade resulting in a physiological response. Isoamyl acetate, for example, functions as a pheromone in some species, and due to its volatile nature, it can activate V1RC21 by binding and stabilizing the receptor's active form. Similarly, propyl acetate and ethyl butyrate, both of which are used as flavor or fragrance additives, activate V1RC21 by mimicking the structure of potential natural ligands, leading to signal propagation in olfactory sensory neurons. Methyl salicylate, known for its wintergreen scent, and benzaldehyde, with its almond-like aroma, can both bind to V1RC21's ligand-binding site, facilitating G-protein signal transduction pathways. These interactions suggest that the receptor has an affinity for a variety of aromatic and volatile compounds, which allows these different chemicals to serve as activators.
Continuing with this theme, cinnamaldehyde and limonene, which are compounds naturally occurring in cinnamon and citrus oils respectively, can activate V1RC21 by interfacing with the ligand-binding domain, thereby driving G-protein activation and initiating cellular responses. Ethyl vanillin and linalool, which are synthetic vanilla scent and floral odor components, also serve as activators of V1RC21 by binding to the active site of the receptor. This interaction triggers conformational changes that lead to downstream signaling. Furthermore, eugenol, heptanal, and octanal are all capable of activating V1RC21 through similar mechanisms. Eugenol, with its presence in clove oil, heptanal's aldehyde structure, and octanal's longer carbon chain, can each bind to the ligand-binding domain of V1RC21, promoting the receptor's active conformation and initiating the G-protein signaling pathway. This variety of chemicals demonstrates the versatility of V1RC21's ligand-binding capabilities and underscores the receptor's potential role in detecting a broad range of scent molecules.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
This ester is known for its role as a pheromone in honeybees. In mammals, similar volatile compounds can activate V1RC21 by binding to and stabilizing the active conformation of the receptor, triggering a signal transduction cascade that results in a physiological response. | ||||||
Propyl acetate | 109-60-4 | sc-250792 | 500 ml | $20.00 | ||
Often used as a flavor or fragrance additive, this ester can activate V1RC21 as it mimics the structure of potential ligands that bind to the olfactory receptors, leading to activation and signal propagation in olfactory sensory neurons. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate is a fruity-smelling ester that can activate V1RC21 by mimicking the action of endogenous scent molecules, binding to the receptor's ligand-binding domain and initiating a G-protein-coupled receptor pathway. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
This organic ester, commonly known as wintergreen oil, has the potential to activate V1RC21 by binding to the receptor's ligand-binding site, thereby initiating a G-protein signal transduction pathway that leads to cellular responses. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
As a naturally occurring compound in cinnamon, cinnamaldehyde can activate V1RC21 through interaction with the ligand-binding domain of the receptor, initiating a signaling cascade via G-protein activation. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
A prominent compound in citrus oils, limonene can activate V1RC21 due to its structure that resembles natural odorant molecules, binding and activating the receptor, thereby producing a cellular response. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
This synthetic compound mimics the odor profile of vanilla and can activate V1RC21 by binding to the receptor's active site, leading to conformational changes that trigger downstream signaling pathways. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Known for its floral scent, linalool can activate V1RC21 by acting as an agonist, interacting with the receptor's ligand-binding site and inducing activation of the associated G-protein signaling cascade. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Found in clove oil, eugenol has the capacity to activate V1RC21 through interaction with the receptor's ligand-binding domain, mimicking natural activators and triggering a signal transduction pathway. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
This aldehyde is a potential odorant that can activate V1RC21 by binding to its ligand-binding domain, which leads to activation of the receptor and subsequent G-protein-coupled signaling events in olfactory neurons. | ||||||