V1RA6 Inhibitors
V1RA6 inhibitors pertain to a class of chemical compounds that interact specifically with a biological target known as the V1RA6 receptor. The V1RA6 receptor is a part of a larger family of receptors that are integral to various biochemical signaling pathways within organisms. The inhibitors are designed to bind to these receptors and modulate their activity, which can influence the biochemical cascade that follows receptor activation. These compounds are characterized by their ability to selectively interact with the V1RA6 receptor, often with high affinity and specificity, which makes them distinct in their action compared to other receptor-targeting molecules.
The molecular architecture of V1RA6 inhibitors is diverse, encompassing a range of structures from small molecules to more complex chemical entities. The design of these inhibitors is informed by an in-depth understanding of the receptor's structure and the key interaction points that are critical for its function. Typically, these inhibitors work by occupying the binding site of the receptor or by altering its conformation in a way that affects its ability to participate in normal signaling processes. The development of V1RA6 inhibitors involves rigorous chemical synthesis and iterative optimization processes to enhance their selectivity and binding characteristics. Researchers employ various techniques such as structure-activity relationship (SAR) studies, computational modeling, and empirical testing to refine these compounds. The inhibitors' efficacy is measured by their ability to modulate the receptor's activity in the desired manner, which is evaluated through a series of biochemical assays and analytical methods.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olmesartan acid | 144689-24-7 | sc-219481 sc-219481A sc-219481B sc-219481C sc-219481D | 10 mg 500 mg 1 g 2 g 5 g | $153.00 $204.00 $326.00 $523.00 $1051.00 | 7 | |
Angiotensin II receptor blocker (ARB) that specifically antagonizes the angiotensin II receptor type 1 (AT1). V1RA6, being a variant of this receptor, would be inhibited by Olmesartan, leading to a decrease in vasoconstriction and aldosterone secretion. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Another ARB, Losartan selectively blocks the AT1 receptor. By binding to this receptor, Losartan prevents V1RA6 from responding to angiotensin II, effectively reducing its ability to modulate blood pressure and electrolyte balance. | ||||||
Eprosartan | 133040-01-4 | sc-207631 | 10 mg | $166.00 | 1 | |
Eprosartan is an ARB that competes with angiotensin II for binding to the AT1 receptor. Inhibition of V1RA6 by eprosartan would result in vasodilation and reduced blood volume. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $39.00 $90.00 $120.00 | 4 | |
As an ARB, Valsartan selectively inhibits the AT1 receptor, which is the primary functional receptor for angiotensin II. Valsartan's blockade of the AT1 receptor would indirectly inhibit V1RA6's ability to increase blood pressure. | ||||||
Telmisartan | 144701-48-4 | sc-204907 sc-204907A | 50 mg 100 mg | $71.00 $92.00 | 8 | |
Telmisartan acts as an ARB with high affinity for the AT1 receptor. By occupying this receptor, Telmisartan inhibits V1RA6's physiological effects, such as vasoconstriction, aldosterone release, and sodium retention. | ||||||
Irbesartan | 138402-11-6 | sc-218603 sc-218603A | 10 mg 50 mg | $104.00 $297.00 | 3 | |
Irbesartan is an ARB that prevents angiotensin II from activating the AT1 receptor. The inhibition of V1RA6 by Irbesartan leads to diminished vasoconstrictive and aldosterone-secreting effects. | ||||||
Candesartan | 139481-59-7 | sc-217825 sc-217825B sc-217825A | 10 mg 100 mg 1 g | $46.00 $92.00 $148.00 | 6 | |
This ARB, Candesartan, blocks the AT1 receptor and, by extension, inhibits the V1RA6 protein from exerting its effects on blood pressure and water balance. | ||||||
Azilsartan | 147403-03-0 | sc-503231 sc-503231A sc-503231B sc-503231C sc-503231D sc-503231E | 10 mg 50 mg 100 mg 250 mg 500 mg 1 g | $140.00 $180.00 $230.00 $370.00 $490.00 $781.00 | ||
An ARB, Azilsartan selectively inhibits AT1 receptor-mediated responses. By doing so, it prevents V1RA6 from contributing to hypertension and related pathophysiological conditions. | ||||||
Ramipril | 87333-19-5 | sc-205833 sc-205833A sc-205833B sc-205833C sc-205833D | 500 mg 1 g 2 g 5 g 10 g | $175.00 $240.00 $357.00 $719.00 $1229.00 | 1 | |
As an ACE inhibitor, Ramipril reduces the production of angiotensin II, leading to decreased activation of V1RA6 and its associated effects on increasing blood pressure and water retention. | ||||||