Date published: 2026-1-16

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v-Maf Activators

v-Maf Activators encompass a diverse group of chemical compounds that indirectly augment the functional activity of v-Maf through a variety of signaling pathways and cellular mechanisms. Phorbol 12-myristate 13-acetate (PMA) enhances v-Maf activity by activating protein kinase C, which can lead to the phosphorylation and modulation of transcription factors and associated proteins, thus influencing v-Maf's transcriptional control over target genes. Forskolin, Isoproterenol, and Dibutyryl cyclic AMP (db-cAMP) share a common mechanism of increasing intracellular cAMP levels, thereby activating protein kinase A (PKA). Activated PKA may then target substrates that can have a positive regulatory effect on v-Maf, such as enhancing its affinity for DNA or interaction with coactivators. Retinoic acid can modulate v-Maf activity by influencing its heterodimerization with retinoic acid receptors, which shapes the transcriptional response of v-Maf target genes. Epigallocatechin gallate (EGCG) and Curcumin exert their effects by modifying the epigenetic landscape, either through inhibition of DNA methyltransferases or by modulating multiple signaling pathways, potentially creating a more favorable environment for v-Maf function.

The histone acetylation status, which is essential for an accessible chromatin conformation, is influenced by compounds like Trichostatin A (TSA), Sodium butyrate, and Sulforaphane, which inhibit histonedeacetylases (HDACs). This inhibition results in a relaxed chromatin structure, potentially enhancing the transcriptional activity of v-Maf by facilitating its access to DNA binding sites. Similarly, S-Adenosylmethionine (SAM) influences the methylation status of DNA and histones, which could indirectly affect the activity of v-Maf by altering gene expression patterns. Lithium chloride's inhibition of GSK-3 may stabilize the interactions between v-Maf and its coactivators or target genes, leading to increased transcriptional activity. Collectively, these activators exert their influence through a cascade of biochemical events that ultimately converge on the enhancement of v-Maf's function as a transcription factor, underscoring the intricate network of cellular signaling that governs its activity.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Adenosine 3′,5′-cyclic monophosphate

60-92-4sc-217584
sc-217584A
sc-217584B
sc-217584C
sc-217584D
sc-217584E
100 mg
250 mg
5 g
10 g
25 g
50 g
$116.00
$179.00
$265.00
$369.00
$629.00
$1150.00
(1)

db-cAMP is a cAMP analog that can activate PKA, which may enhance v-Maf activity through phosphorylation of associated factors or alteration of its own phosphorylation state.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin can modulate various signaling pathways and transcription factors, possibly leading to an enhanced chromatin environment and transcriptional activity for v-Maf.