UQCRHL Activators
Chemical activators of UQCRHL play pivotal roles in modulating its function within the mitochondrial electron transport chain. Coenzyme Q10, Decylubiquinone, and Mitoquinone, by their nature as ubiquinone analogs, directly participate in electron transfer within the mitochondrial inner membrane. These molecules facilitate the shuttling of electrons between complexes in the electron transport chain, enhancing the electron flux through UQCRHL, an essential component of complex III. Similarly, the presence of NADH ensures a steady supply of electrons, which is crucial for the initiation of the electron transport chain, subsequently leading to the activation of UQCRHL. Succinic acid, serving as a substrate for complex II, increases the supply of electrons, thereby indirectly elevating the activity of UQCRHL by increasing the electron flow through the chain.
Furthermore, the binding of Antimycin A to complex III initially inhibits the Q-cycle, which can trigger a compensatory increase in UQCRHL activity to restore electron flow. Ascorbic acid and Glutathione, as antioxidants, maintain the redox balance, which is critical for the function of the electron transport chain, thereby promoting the activation of UQCRHL. Cytochrome c, accepting electrons from complex III, can enhance the transfer efficiency, leading to the activation of UQCRHL. The antioxidants, Tempol and Trolox, protect the electron transport chain from oxidative stress, indirectly supporting UQCRHL activation by ensuring the functional integrity of the complex. Ubiquinol, being the reduced form of Coenzyme Q10, is also integral to electron transport, further reinforcing the activation of UQCRHL as it facilitates electron transfer within complex III. These chemical activators ensure the proper functioning of UQCRHL by either directly participating in the electron transfer or by maintaining the optimal conditions for its activity within the mitochondrial electron transport chain.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 supports the electron transport chain, in which UQCRHL is involved, by serving as a mobile electron carrier between complexes I/II and complex III, thereby enhancing the functional activity of UQCRHL in this process. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
Succinic acid acts as a substrate for complex II (succinate dehydrogenase) in the mitochondrial electron transport chain, which indirectly increases the electron flux through UQCRHL, part of complex III, thus activating its function. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A binds to the Qi site of complex III and inhibits the Q-cycle, which can lead to the activation of UQCRHL as a compensatory mechanism to overcome the inhibition, and restore electron flow. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid can donate electrons to complex IV, which can cause a compensatory increase in the activity of upstream proteins in the electron transport chain, including UQCRHL, to maintain redox balance. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Glutathione can maintain redox balance within the cell, which is critical for the proper function of the electron transport chain, thereby supporting the activation of UQCRHL. | ||||||
Decylubiquinone | 55486-00-5 | sc-358659 sc-358659A | 10 mg 50 mg | $69.00 $260.00 | 10 | |
Decylubiquinone serves as an analog of Coenzyme Q10 and can act as an electron carrier within the electron transport chain, enhancing the functional activity of UQCRHL. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NADH is a primary electron donor in the electron transport chain, and its presence can enhance the activity of the entire chain, including the functional activation of UQCRHL within complex III. | ||||||
TEMPOL | 2226-96-2 | sc-200825 | 1 g | $36.00 | 33 | |
Tempol is a synthetic antioxidant that can mimic the action of superoxide dismutase, potentially increasing the efficiency of the electron transport chain and hence the activity of UQCRHL. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $37.00 $66.00 $230.00 $665.00 $1678.00 | 39 | |
Trolox is a water-soluble analog of Vitamin E that can protect the electron transport chain from oxidative stress, indirectly supporting the activation of UQCRHL by maintaining the integrity of the complex in which it is involved. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
Mitoquinone is a derivative of Coenzyme Q10 targeted to mitochondria, and it can enhance the electron transport chain's efficiency, activating UQCRHL as part of this essential cellular process. | ||||||