UGT2B34 Activators
Chemical activators of UGT2B34 can significantly enhance its enzymatic function by various mechanisms. Magnesium sulfate plays a pivotal role in the activation of UGT2B34 by providing magnesium ions, which are necessary cofactors for the enzyme's glucuronidation process. These ions bind to UGT2B34, facilitating the structural conformation required for its catalytic activity. Similarly, zinc chloride contributes zinc ions, which can further augment the enzyme's activity. These ions may improve the binding of substrates or stabilize the UGT2B34 structure, enhancing its enzymatic efficiency. Furthermore, UDP-Glucuronic acid is a critical substrate for UGT2B34, directly participating in the glucuronidation reaction. The presence of UDP-Glucuronic acid is quintessential for the activation of UGT2B34, as it is utilized in the catalytic process to attach glucuronic acid to target molecules.
Beyond these direct activators, several other compounds contribute to an optimal environment that supports the activity of UGT2B34. Sodium sulfate, by providing sulfate ions, may assist in maintaining the tertiary structure of UGT2B34, thereby preserving its active conformation. Similarly, calcium chloride and potassium chloride are sources of calcium and potassium ions, respectively, which help in maintaining the cellular ionic balance and an environment conducive to enzymatic activity. The provision of sodium phosphate helps buffer the cellular pH, creating stable conditions for UGT2B34 function. Tris buffer also plays a critical role in maintaining a suitable pH, ensuring the enzyme's structural integrity. Glycerol acts as a stabilizer for UGT2B34, contributing to maintaining its functional conformation. Although ATP is known as an activator for many enzymes, in the case of UGT2B34, it can facilitate the necessary conformational changes required for activation. Lastly, the presence of NADPH is crucial in maintaining a reductive environment, which is beneficial for the general function of enzymes, including UGT2B34.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium ions are essential cofactors for the UGT2B34 enzyme, as they are required for the glucuronidation process. Magnesium sulfate provides magnesium ions, which can directly activate UGT2B34 by binding to the enzyme and facilitating its catalytic activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can act as a cofactor for UGT2B34, enhancing its enzymatic activity. Zinc chloride is a source of zinc ions, which when available in the cellular environment, can activate UGT2B34 by improving substrate binding or stabilizing the protein structure for efficient catalysis. | ||||||
Sodium sulfate anhydrous | 7757-82-6 | sc-212945 sc-212945A | 500 g 1 kg | $63.00 $91.00 | ||
Sodium sulfate can provide sulfate ions, which could be necessary for the proper folding and function of UGT2B34. Though not a direct activator, sulfate ions from sodium sulfate can maintain the tertiary structure of the protein, thus maintaining its active conformation and promoting its enzymatic activity. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions may not directly activate UGT2B34, but they play a crucial role in the overall cellular environment where UGT2B34 functions. Calcium chloride contributes calcium ions that can influence the phosphorylation state of proteins and cellular signaling pathways that are essential for the proper functioning of UGT2B34. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $55.00 $155.00 $285.00 $455.00 | 5 | |
Potassium ions are important for maintaining cellular ionic strength and pH, which can affect enzyme structure and function. Potassium chloride provides potassium ions that can help in maintaining an optimal environment for UGT2B34 activation and function. | ||||||
Sodium phosphate | 7601-54-9 | sc-251041 sc-251041A | 25 g 500 g | $42.00 $47.00 | ||
Sodium phosphate can buffer the cellular environment and maintain a pH that is conducive to the optimal activity of UGT2B34. By stabilizing the pH, sodium phosphate indirectly supports the activation of UGT2B34 by providing a stable environment for its enzymatic action. | ||||||
Glycerol | 56-81-5 | sc-29095A sc-29095 | 100 ml 1 L | $56.00 $153.00 | 12 | |
Glycerol is often used as a stabilizing agent in protein solutions. By stabilizing the protein, glycerol can help maintain the active conformation of UGT2B34, thus indirectly supporting its enzymatic activity. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP is a direct activator of many enzymes and can serve as a signaling molecule within the cell. For UGT2B34, ATP can provide the energy required for the conformational changes that activate the enzyme for its glucuronidation function. | ||||||
NADPH tetrasodium salt | 2646-71-1 | sc-202725 sc-202725A sc-202725B sc-202725C | 25 mg 50 mg 250 mg 1 g | $47.00 $84.00 $286.00 $754.00 | 11 | |
NADPH is a cofactor used in various enzymatic reactions to donate electrons. While not directly activating UGT2B34, NADPH can maintain a reductive environment in the cell, which is essential for the proper function of UGT2B34 as well as many other enzymes. | ||||||