Date published: 2025-10-15

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Sodium phosphate (CAS 7601-54-9)

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Alternate Names:
Trisodium phosphate; TSP
Application:
Sodium phosphate is a water-soluble reagent widely used as a cleaning agent and often used in the formulation of various buffers
CAS Number:
7601-54-9
Purity:
≥98%
Molecular Weight:
163.94
Molecular Formula:
Na3PO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium phosphate (TSP) is water-soluble and widely used as a cleaning agent. The pH of a 1% solution is typically around 12, making this reagent sufficiently alkaline for saponification of grease and oils. Often used in the formulation of various buffers complementary buffer components may include: Sodium phosphate monobasic (sc-215883 sc-251042), Sodium phosphate dibasic (sc-203277 sc-236917) or Potassium Phosphate, Dibasic (sc-203210). Sodium phosphate is used in the isolation of mycobacteria, including culturing of tubercle bacilli. It has been used as a protein precipitant in certain applications and in co-precipitation and fractionization of nucleotides. Sodium phosphate may be used for the preservation of biologically active soil samples. Because of the alkaline pH, Sodium phosphate disrupts cytoplasmic and outer membranes of Salmonella enterica cells making it useful in preventing the spread of bacteria. Also available: Sodium phosphate tribasic dodecahydrate (sc-203403).


Sodium phosphate (CAS 7601-54-9) References

  1. High pH during trisodium phosphate treatment causes membrane damage and destruction of Salmonella enterica serovar enteritidis.  |  Sampathkumar, B., et al. 2003. Appl Environ Microbiol. 69: 122-9. PMID: 12513986
  2. Simultaneous determination of methyl tert-butyl ether, its degradation products and other gasoline additives in soil samples by closed-system purge-and-trap gas chromatography-mass spectrometry.  |  Rosell, M., et al. 2006. J Chromatogr A. 1132: 28-38. PMID: 16904119
  3. Trisodium phosphate in culturing for tubercle bacilli.  |  ARMSTRONG, AR. 1948. Can Med Assoc J. 59: 73. PMID: 18864250
  4. Sodium phosphate as an ergogenic aid.  |  Buck, CL., et al. 2013. Sports Med. 43: 425-35. PMID: 23568374
  5. Trisodium phosphate and sodium hypochlorite are more effective as antimicrobials against Campylobacter and Salmonella on duck as compared to chicken meat.  |  Sarjit, A. and Dykes, GA. 2015. Int J Food Microbiol. 203: 63-9. PMID: 25791251
  6. Renal risk associated with sodium phosphate medication: safe in healthy individuals, potentially dangerous in others.  |  Hoffmanová, I., et al. 2015. Expert Opin Drug Saf. 14: 1097-110. PMID: 26084636
  7. A Synergy Effect of Trisodium Phosphate and Ethanol on Inactivation of Murine Norovirus 1 on Lettuce and Bell Pepper.  |  Kim, EJ., et al. 2015. J Microbiol Biotechnol. 25: 2106-9. PMID: 26323270
  8. Effect of trisodium phosphate dipping treatment on the quality and energy metabolism of apples.  |  Ge, Y., et al. 2019. Food Chem. 274: 324-329. PMID: 30372946
  9. Effects of trisodium phosphate treatment after harvest on storage quality and sucrose metabolism in jujube fruit.  |  Zhang, J., et al. 2019. J Sci Food Agric. 99: 5526-5532. PMID: 31102411
  10. Combining salicylic acid and trisodium phosphate alleviates chilling injury in bell pepper (Capsicum annuum L.) through enhancing fatty-acid desaturation efficiency and water retention.  |  Ge, W., et al. 2020. Food Chem. 327: 127057. PMID: 32464461
  11. Microbial Decontamination of Beef Carcass Surfaces by Lactic Acid, Acetic Acid, and Trisodium Phosphate Sprays.  |  Sallam, KI., et al. 2020. Biomed Res Int. 2020: 2324358. PMID: 33204685
  12. The effect of trisodium phosphate crosslinking on the diffusion kinetics of caffeine from chitosan networks.  |  Morrish, C., et al. 2022. Food Chem. 381: 132272. PMID: 35123227
  13. Isolation and characterization of nitrate reductase from Escherichia coli.  |  MacGregor, CH. 1978. Methods Enzymol. 53: 347-55. PMID: 362126
  14. Isolation of cyclic AMP by inorganic salt coprecipitation.  |  Chan, PS. and Lin, MC. 1974. Methods Enzymol. 38: 38-41. PMID: 4375771
  15. Direct comparison of the N-acetyl-l-cysteine-sodium hydroxide and the trisodium phosphate digestion methods for the culture of mycobacteria.  |  Martin, ME., et al. 1968. Appl Microbiol. 16: 506-8. PMID: 4967759

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium phosphate, 25 g

sc-251041
25 g
$41.00

Sodium phosphate, 500 g

sc-251041A
500 g
$46.00