UBE2D3 Activators
UBE2D3, ubiquitin-conjugating enzyme E2 D3, plays a critical role in the ubiquitination pathway, a fundamental cellular process for protein degradation and regulation. This enzyme is involved in attaching ubiquitin to target proteins, marking them for degradation by the proteasome or altering their cellular location and function. The specificity and activity of UBE2D3 are regulated through interactions with various proteins, including E3 ubiquitin ligases, which recognize substrate proteins. The regulation of UBE2D3 activity is essential for maintaining cellular protein homeostasis, responding to stress, and regulating cell cycle progression.
The functional activation of UBE2D3 involves complex mechanisms, including post-translational modifications and interactions with co-factors that enhance its ability to conjugate ubiquitin to substrates. Activation can be influenced by cellular stress, signaling pathways, and the availability of cofactors and substrates. Chemicals that indirectly activate UBE2D3 generally do so by influencing these regulatory mechanisms or the cellular environment. For instance, compounds that induce cellular stress or modulate signaling pathways can enhance the activity of UBE2D3 by increasing the need for protein degradation or by altering the availability of substrates and cofactors. This highlights the importance of understanding the broader cellular context in which UBE2D3 operates, as well as the interconnectedness of cellular pathways that can impact its activity. Activation of UBE2D3, therefore, is not just about the direct interaction with activators but also involves a network of cellular responses that facilitate its function in the ubiquitin-proteasome system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Also called zinc pyrithione, this compound activates UBE2D3 by enhancing its ubiquitin ligase activity. By binding directly to the protein, it stabilizes UBE2D3 and increases its interaction with substrates, leading to an enhanced ubiquitination process. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 indirectly activates UBE2D3 by inhibiting proteasomal degradation pathways. This accumulation leads to increased levels of UBE2D3 in the cell, thereby enhancing its activity and the ubiquitination of its target proteins. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can activate the PI3K/AKT pathway, indirectly influencing ubiquitination events and UBE2D3 activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, indirectly activates UBE2D3 by altering chromatin structure and accessibility. This modification can lead to an enhanced expression of proteins involved in the ubiquitination pathway, supporting UBE2D3's functional activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin increases intracellular calcium levels, indirectly activating UBE2D3 by affecting calcium-dependent signaling pathways. This elevation in calcium can enhance the enzymatic activity of UBE2D3 by promoting its interaction with target substrates for ubiquitination. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin, a calcium ionophore, indirectly activates UBE2D3 through the elevation of intracellular calcium, similar to thapsigargin. This activation promotes the ubiquitination process by facilitating UBE2D3's interaction with its substrates. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite induces oxidative stress, leading to the indirect activation of UBE2D3. The stress response triggers cellular pathways that enhance the activity of ubiquitination enzymes, including UBE2D3, as part of the cell's effort to degrade misfolded proteins. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90, inhibiting its function and indirectly activating UBE2D3 by releasing it from Hsp90-associated inhibitory complexes. This leads to increased activity of UBE2D3 in targeting proteins for degradation. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A disrupts cytoskeletal organization, leading to an indirect activation of UBE2D3. This disruption enhances the ubiquitination process by facilitating the access of UBE2D3 to its substrates within the cell. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin, by inhibiting N-linked glycosylation, induces ER stress and indirectly activates UBE2D3 as part of the unfolded protein response, enhancing its activity in degrading misfolded proteins through ubiquitination. | ||||||