TYW1 Activators
TYW1 activators are a class of chemical compounds that interact with the enzyme TYW1, a member of the radical SAM (S-adenosylmethionine) superfamily of enzymes. TYW1, which stands for "tRNA-yW synthesizing protein 1," is an enzyme that plays a crucial role in the biosynthesis of wybutosine (yW), a hypermodified nucleoside found at position 37 of certain phenylalanine tRNAs in eukaryotes and archaea. Wybutosine and its derivatives are important for maintaining the fidelity of genetic code translation by stabilizing the correct codon-anticodon pairing during protein synthesis. The activation of TYW1 by these chemical compounds is of significant interest in the field of biochemistry and molecular biology due to the importance of post-transcriptional modifications in cellular function and gene expression.
The mechanism by which TYW1 activators function involves the modulation of the enzyme's activity, which is responsible for catalyzing multiple steps in the complex pathway of wybutosine synthesis. These steps often involve intricate chemical reactions, such as the transfer of methyl groups, reduction, and thiolation, which contribute to the formation of the wybutosine structure. The precise chemical nature of TYW1 activators can vary, encompassing a range of molecular structures and properties designed to interact with the enzyme's active site or allosteric sites. This interaction can enhance the enzyme's natural activity, influencing the rate at which it catalyzes the reactions in the wybutosine biosynthetic pathway. Understanding the biochemical properties of TYW1 activators, including their binding affinity, specificity, and the stability of the activated enzyme complex, is essential for elucidating the intricacies of tRNA modification and its broader implications on cellular metabolism.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
S-Adenosylmethionine serves as a methyl donor in various biological methylation reactions, including the methylation step catalyzed by TYW1 in the biosynthesis of wybutosine, a hypermodified nucleoside in tRNA. This methylation is essential for the activation and function of TYW1. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for numerous enzymes including TYW1. It is required for the structural integrity and catalytic activity of TYW1. By binding to the active site, zinc can enhance the functional activity of TYW1 in catalyzing the modification of tRNA. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium ions are crucial for the function of many enzymes, including RNA-modifying enzymes like TYW1. Magnesium chloride can supply these ions, potentially enhancing the catalytic activity of TYW1 by stabilizing the transition state of the reaction or facilitating the binding of substrates. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal phosphate is a vitamin B6 derivative that acts as a cofactor for various enzymatic activities, including decarboxylation and transamination reactions. TYW1 may utilize this cofactor for the formation of wybutosine intermediates, indirectly enhancing its functional activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is involved in redox reactions, serving as an electron carrier. It can indirectly enhance the activity of TYW1 by maintaining a favorable redox state that is essential for the function of many enzymes, including those involved in tRNA modification. | ||||||
Folinic Acid | 58-05-9 | sc-337846A sc-337846B sc-337846 | 5 mg 25 mg 100 mg | $112.00 $297.00 $604.00 | ||
Folinic acid, or 5-formyltetrahydrofolate, is involved in the transfer of one-carbon units in metabolism. It can supply methyl groups required for the methylation reaction catalyzed by TYW1, thus potentially enhancing its function in wybutosine synthesis. | ||||||
Mecobalamin | 13422-55-4 | sc-211781 | 10 mg | $306.00 | ||
Methylcobalamin is a form of vitamin B12 that acts as a coenzyme in methylation reactions. It can donate a methyl group for the reaction catalyzed by TYW1, enhancing its activity in the synthesis of wybutosine. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $51.00 $112.00 $449.00 $1151.00 $2178.00 | 1 | |
L-Cysteine can potentially enhance the function of TYW1 as it provides sulfhydryl groups that may be involved in maintaining the proper tertiary structure of proteins, including TYW1, thereby enhancing its catalytic activity. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
L-Methionine is an essential amino acid that can be used as a methyl donor in various methylation reactions. It may indirectly enhance the activity of TYW1 by providing the substrate necessary for the methylation process in wybutosine synthesis. | ||||||
Iron(II) sulfate solution | 10028-21-4 | sc-224024 | 1 each | $46.00 | ||
Iron is a cofactor for a wide range of enzymes. It can indirectly enhance the function of TYW1 by participating in the synthesis of cofactors or substrates required by TYW1 for its catalytic activity. | ||||||