Type I 4-phoshatase α Inhibitors
The chemical class of Type I 4-phosphatase α inhibitors would include a wide range of compounds, given the lack of specificity of the term "Type I 4-phosphatase α." In general, phosphatase inhibitors function by either mimicking the transition state of the enzyme's natural substrate, chelating necessary metal ions in the active site, or binding to active site residues to prevent catalysis.
Inhibitors like sodium orthovanadate and sodium fluoride act by mimicking phosphate groups or by forming complexes with catalytic metal ions. Cantharidin and calyculin A are natural toxins that inhibit protein phosphatases through covalent modification or by binding tightly to the active site. Okadaic acid and microcystin-LR, both produced by marine organisms, are potent inhibitors of PP2A and PP1, often used in research to study cellular phosphorylation processes. Tautomycetin is a more selective inhibitor that allows for differential inhibition of phosphatases.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
A non-specific inhibitor of protein tyrosine phosphatases; it acts by mimicking the transition state of phosphate esters, thus blocking the active site of the phosphatase. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Commonly used to inhibit serine/threonine phosphatases by forming complexes with the catalytic metal ions in the active site. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
A potent and selective inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which may indirectly affect the signaling pathways involving Type I 4-phosphatase α. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
An inhibitor of PP1 and PP2A, which may also have broader effects on the phosphatase enzyme family. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $49.00 $203.00 | 1 | |
Acts as a phosphatase inhibitor by chelating the metal ions necessary for enzyme activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
A potent inhibitor of PP2A and PP1, it can indirectly affect the signaling related to Type I 4-phosphatase α by altering the phosphorylation status of downstream targets. | ||||||
Epothilone A | 152044-53-6 | sc-207628 sc-207628A | 10 µg 1 mg | $210.00 $1000.00 | 1 | |
Selectively inhibits PP1 over PP2A, potentially affecting the activity of related phosphatases such as Type I 4-phosphatase α. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $41.00 | 4 | |
Inhibits protein tyrosine phosphatases by binding to vicinal thiol groups in the active site. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $265.00 | 9 | |
Preferentially inhibits PP2A and PP4, which could indirectly influence Type I 4-phosphatase α signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Although primarily a calcium ionophore, it can disrupt cellular signaling pathways and indirectly affect phosphatase activity. | ||||||