Sodium Orthovanadate CAS: 13721-39-6
MF: Na3O4V
MW: 183.91

Sodium Orthovanadate (CAS 13721-39-6)

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Nomes alternativos: Sodium Orthovanadate is also known as Vanadate.
Aplicação Sodium Orthovanadate is a potent inhibitor of several alkaline phosphatases and tyrosine phosphates with an IC50 of 10 µM.
Numero VAT: 13721-39-6
Privada: ≥99%
Peso Molecular: 183.91
Separar por Funcao: Na3O4V
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
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Sodium Orthovanadate is a commonly used general inhibitor for protein tyrosine phosphatases (PTPs), alkaline phosphatase (ALP) and ATPase. Sodium Orthovanadate acts as a competitive inhibitor and is completely reversible upon the addition of EDTA or by dilution. The PTP activities of Sodium Orthovanadate are conveniently separable from the protein phosphoseryl and phosphothreonyl phosphatase (PSP) activities inhibited by Fluoride and EDTA. Sodium Orthovanadate is routinely used to preserve the protein tyrosyl phosphorylation state in cells, cell lysates, and protein tyrosine kinase assays.


Referencias

1. Gordon, J.A. 1991. Meth. Enzymol. 201 : 477-482. PMID: 1943774
2. Huyer, G. et al. 1997. J. Biol. Chem. 272(2): 843-851. PMID: 8995372
3. Wu DN, et al. Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus. Neurosci Lett. 2006 Aug 14;404(1-2):98-102.

Paginas :
Sodium orthovanadate stock solutions (1 mM or higher, as desired) may be prepared in water with the pH adjusted to pH ~10. To ensure the presence of vanadate monomers, boil the solution until translucent and readjust the pH to 10. The precise concentration of a dilute aqueous solution (pH 10.5) may be determined using the molar extinction coefficient (eM= 3,550 at 260 nm). Orange color observed before boiling is due to decavanadate. At pH 10, decavanadate will slowly depolymerize over several hours to the colorless monovanadate; however, the process is accelerated by boiling.

Store solutions at -20κC.
Aparência :
Powder
Estado físico :
Solid
envie :
Soluble in water (50 mg/ml, clear to hazy, colorless to faint yellow solution).
Manutencao :
Store at room temperature
Ponto de fusão :
850-866° C (lit.)
Ponto de fervura :
3380° C (lit.)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
YW1120000
PubChem CID :
Numero de FAX :
MFCD00003511
Numero de FAX :
237-287-9
Registro Beilstein :
12153548
SMILES :
[O-][V](=O)([O-])[O-].[Na+].[Na+].[Na+]

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Sodium Orthovanadate (CAS 13721-39-6)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Sodium Orthovanadate (CAS 13721-39-6). Clique em PubMed para ver .

Citações 1 para 10 de 129 total

PMID: # 33558531  Ye, Z.|Gould, TM.|Zhang, H.|Jin, J.|Weyand, CM.|Goronzy, JJ.| et al. 2021. NPJ Aging Mech Dis. 7: 4.

PMID: # 33917576  Cho, GW.|Moon, C.|Song, A.|Vijayakumar, KA.|Ang, MJ.|Jang, CH.| et al. 2021. J Clin Med. 10:

PMID: # 33560226  Tuvikene, J.|Esvald, EE.|Rähni, A.|Uustalu, K.|Zhuravskaya, A.|Avarlaid, A.|Makeyev, EV.|Timmusk, T.| et al. 2021. Elife. 10:

PMID: # 33761359  Higuchi, M.|Ishiyama, K.|Maruoka, M.|Kanamori, R.|Takaori-Kondo, A.|Watanabe, N.| et al. 2021. Cell Rep. 34: 108876.

PMID: # 33706506  Honda, S.|Minagawa, Y.|Noji, H.|Tabata, KV.| et al. 2021. Anal Chem.

PMID: # 32468435  Jantararussamee, C.|Rodniem, S.|Taweechotipatr, M.|Showpittapornchai, U.|Pradidarcheep, W.| et al. 2020. Probiotics Antimicrob Proteins.

PMID: # 30917306  Figard, L.|Zheng, L.|Biel, N.|Xue, Z.|Seede, H.|Coleman, S.|Golding, I.|Sokac, AM.| et al. 2019. Cell Rep. 26: 3493-3501.e4.

PMID: # 31112013  Amara, I.|Timoumi, R.|Graiet, I.|Ben Salem, I.|Adelou, K.|Abid-Essefi, S.| et al. 2019. Environ Toxicol. 34: 1034-1042.

PMID: # 31441677  2019. Am. J. Physiol. Heart Circ. Physiol. 29: 818-26.

PMID: # 30322148  Osa-Andrews, B.|Tan, KW.|Sampson, A.|Iram, SH.| et al. 2018. Pharmaceutics. 10:

Citações 1 para 10 de 129 total
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