TSA-1 Activators
TSA-1 Activators encompass a variety of chemical compounds that, through distinct signaling pathways, indirectly enhance the functional activity of TSA-1. Forskolin and IBMX exemplify molecules that elevate intracellular cAMP and cGMP levels, respectively, thereby activating Protein Kinase A (PKA) and other cAMP/cGMP-dependent pathways that can phosphorylate substrates interacting with TSA-1, leading to its enhanced activity. Similarly, Epigallocatechin Gallate (EGCG) targets tyrosine kinases, thereby potentially freeing TSA-1 associated pathways from competitive inhibition, while Sphingosine-1-phosphate (S1P) taps into lipid signaling to modulate pathways that can activate TSA-1. Thapsigargin and A23187, by increasing intracellular calcium, activate calcium-dependent proteins and pathways that may also enhance TSA-1's role in the cell. PMA, a PKC activator, manipulates other signaling cascades that could pivot towards TSA-1 activation, underscoring the adaptability of cellular signaling networks.
Further extending the repertoire of TSA-1 activators, PD 98059, a MEK inhibitor, represents compounds that, by blocking their respective targets, may inadvertently channel signaling towards TSA-1 activation. Staurosporine, despiteits broad kinase inhibition profile, could preferentially disrupt negative regulatory kinases of TSA-1, thereby acting as an indirect activator. These compounds, through intricate cellular signaling interplay, ensure that the activation of TSA-1 is achieved without the necessity of directly upregulating its expression or employing direct agonists.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA (Protein Kinase A). PKA phosphorylates target proteins that can directly interact with and enhance the functional activity of TSA-1 in signal transduction. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to elevated intracellular levels of these second messengers. This can stimulate pathways that converge on TSA-1 activation, promoting its role in cellular processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a tyrosine kinase inhibitor which can alter cell signaling pathways. By inhibiting competitive signaling routes, it may enhance the pathways that specifically lead to the activation of TSA-1. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P engages with its receptors to activate intracellular signaling pathways, including those that could lead to the functional activation of TSA-1 through cross-talk between lipid signaling and TSA-1 associated pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased intracellular calcium levels, which can activate calcium-dependent proteins and pathways that enhance TSA-1 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator which mimics diacylglycerol (DAG), leading to the activation of Protein Kinase C (PKC). PKC then activates downstream proteins and pathways that can enhance the function of TSA-1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore, facilitating the increase of intracellular calcium concentration, which triggers signaling pathways that can indirectly lead to TSA-1 activation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, which can selectively disrupt inhibitory kinases that regulate TSA-1, ultimately enhancing TSA-1 signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which may enhance TSA-1 activity by inhibiting signaling pathways that negatively regulate TSA-1 function. | ||||||