TRPV Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium red is recognized for its ability to selectively inhibit TRPV channels, primarily through its interaction with specific amino acid residues within the channel's pore region. This compound exhibits a unique binding profile that disrupts the normal conformational changes required for channel activation. Its presence alters the ion selectivity and permeability, leading to significant effects on cellular excitability and signaling pathways. The compound's kinetics reveal a rapid onset of action, contributing to its effectiveness in modulating channel activity. | ||||||
RN 1734 | 946387-07-1 | sc-296273 sc-296273A | 10 mg 50 mg | $131.00 $510.00 | 1 | |
RN 1734 is a potent modulator of TRPV channels, characterized by its unique ability to stabilize specific channel conformations. This compound engages in distinct molecular interactions with key residues, influencing the gating mechanisms and ion flow. Its reaction kinetics demonstrate a delayed onset, allowing for prolonged channel modulation. Additionally, RN 1734 exhibits a selective affinity for certain TRPV subtypes, enhancing its specificity in altering cellular ion dynamics and signaling cascades. | ||||||
AMG-9810 | 545395-94-6 | sc-201477 sc-201477A | 10 mg 50 mg | $86.00 $344.00 | 3 | |
AMG-9810 is a selective modulator of TRPV channels, characterized by its ability to engage in unique hydrogen bonding interactions that stabilize specific channel conformations. This compound exhibits a distinct binding affinity, leading to altered ion flow and channel activation thresholds. Its kinetic profile reveals a delayed onset of action, allowing for prolonged modulation of TRPV activity. Additionally, AMG-9810's structural features enable it to selectively influence TRPV isoform interactions, impacting downstream signaling cascades. | ||||||
JYL-1433 | 565448-40-0 | sc-202676 sc-202676A | 1 mg 5 mg | $200.00 $400.00 | 1 | |
JYL-1433 is a selective TRPV channel modulator that uniquely alters channel dynamics through specific allosteric interactions. It binds to critical sites, inducing conformational changes that affect ion permeability and gating behavior. The compound exhibits rapid kinetics, facilitating swift modulation of channel activity. Its distinct binding profile allows for targeted effects on various TRPV isoforms, influencing cellular excitability and calcium signaling pathways. | ||||||