Molecular structure of AMG-9810, CAS Number: 545395-94-6
AMG-9810 (CAS 545395-94-6)
See product citations (3)
Alternate Names:
2E-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide
Application:
AMG-9810 is a vanilloid receptor antagonist
CAS Number:
545395-94-6
Purity:
≥98%
Molecular Weight:
337.41
Molecular Formula:
C21H23NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AMG-9810, is a VR1 (vanilloid receptor 1) antagonist which blocks all known modes of VR1 activation, including heat, proton, and endogenous ligand activation. VR1 is a membrane-bound cation channel in peripheral sensory neurons. Inhibition of this receptor has been noted to cause anti-inflammatory effects. In murine dorsal root ganglion primary neuron studies, this compound may act to block capsaicin-evoked depolarization and calcitonin gene-related peptide release.
AMG-9810 (CAS 545395-94-6) References
- AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. | Gavva, NR., et al. 2005. J Pharmacol Exp Ther. 313: 474-84. PMID: 15615864
- Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. | Pitcher, MH., et al. 2007. Mol Pain. 3: 17. PMID: 17603899
- Acid-evoked Ca2+ signalling in rat sensory neurones: effects of anoxia and aglycaemia. | Henrich, M. and Buckler, KJ. 2009. Pflugers Arch. 459: 159-81. PMID: 19806360
- Peripheral acid-sensing ion channels and P2X receptors contribute to mechanical allodynia in a rodent thrombus-induced ischemic pain model. | Seo, HS., et al. 2010. J Pain. 11: 718-27. PMID: 20338827
- A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide. | Van Overloop, H., et al. 2012. J Lipids. 2012: 404513. PMID: 22900189
- Endocannabinoid System and TRPV1 Receptors in the Dorsal Hippocampus of the Rats Modulate Anxiety-like Behaviors. | Hakimizadeh, E., et al. 2012. Iran J Basic Med Sci. 15: 795-802. PMID: 23493622
- Involvement of central TRPV1 receptors in pentylenetetrazole and amygdala-induced kindling in male rats. | Shirazi, M., et al. 2014. Neurol Sci. 35: 1235-41. PMID: 24577898
- Blocking of TRPV-1 in the parodontium relieves orthodontic pain by inhibiting the expression of TRPV-1 in the trigeminal ganglion during experimental tooth movement in rats. | Gao, Y., et al. 2016. Neurosci Lett. 628: 67-72. PMID: 27267133
- Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment. | Park, M., et al. 2018. Cell Biol Toxicol. 34: 143-162. PMID: 28815372
- Increased Asics Expression via the Camkii-CREB Pathway in a Novel Mouse Model of Trigeminal Pain. | Wang, Y., et al. 2018. Cell Physiol Biochem. 46: 568-578. PMID: 29617678
- Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats. | Barrett, KT., et al. 2018. Neurobiol Dis. 119: 172-189. PMID: 30121230
- A Single Injection of N-Oleoyldopamine, an Endogenous Agonist for Transient Receptor Potential Vanilloid-1, Induced Brain Hypothermia, but No Neuroprotective Effects in Experimentally Induced Cerebral Ischemia in Rats. | Tejada de Rink, MM., et al. 2020. Ther Hypothermia Temp Manag. 10: 91-101. PMID: 31084468
- Transient Cell Membrane Disruptions induce Calcium Waves in Corneal Keratocytes. | Chen, Z., et al. 2020. Sci Rep. 10: 2840. PMID: 32071321
Inhibitor of:
ANKTM1, Eapa2, MrgA4, MrgB1, MrgH, Olfr1166, Olfr536, Olfr551, Olfr722, OR51I, OTRPC4, PIRT, TRP14, TRPV, V1RL5, Vmn2r28, and VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMG-9810, 10 mg | sc-201477 | 10 mg | $86.00 | |||
AMG-9810, 50 mg | sc-201477A | 50 mg | $344.00 |