JYL-1433 (CAS 565448-40-0)
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Alternate Names:
IUPAC NAME [2-[(3,4-dimethylphenyl)methyl]-3-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Application:
JYL-1433 is a selective transient receptor potential TRPV1 antagonist.
CAS Number:
565448-40-0
Molecular Weight:
537.7
Molecular Formula:
C26H36FN3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JYL-1433 is a selective transient receptor potential vanilloid-1 (TRPV1) antagonist. TRPV1 is a Capsaicin (sc-3577) receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. The compound has been shown to inhibit calcium flux and capsaicin toxicity in epitheliall cell studies.
JYL-1433 (CAS 565448-40-0) References
- Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells. | Reilly, CA., et al. 2005. J Biochem Mol Toxicol. 19: 266-75. PMID: 16173059
- Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1. | Light, AR., et al. 2008. J Neurophysiol. 100: 1184-201. PMID: 18509077
- TRPV1 splice variants: structure and function. | Schumacher, MA. and Eilers, H. 2010. Front Biosci (Landmark Ed). 15: 872-82. PMID: 20515731
- Peripheral Mechanisms of Ischemic Myalgia. | Queme, LF., et al. 2017. Front Cell Neurosci. 11: 419. PMID: 29311839
Inhibitor of:
TRPV.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JYL-1433, 1 mg | sc-202676 | 1 mg | $200.00 | |||
JYL-1433, 5 mg | sc-202676A | 5 mg | $400.00 |