RN 1734 is a selective TRPV4 antagonist (IC50 values are 2.3, 5.9 and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). RN 1734 has been shown to display selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).
Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
XiaXia, Y. et al. (PubMed 23739180) used the TRPV4 antagonist RN 1734 to demonstrate that TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
You may not log in without verifying your email address. Please check your email (including your spam email) for the Welcome message that was sent.
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.
Already have an account?
Please check your email (including your spam email) for a Welcome message, and verify your email address to continue.