Trp53i13 Inhibitors
Trp53i13 inhibitors largely target proteins and pathways that have a direct or indirect relationship with the p53 tumor suppressor protein. Given that Trp53i13 is conceptually linked to p53, modulating p53's activity provides an indirect approach to influencing Trp53i13.
A prevalent approach involves targeting the interaction between p53 and its negative regulator, MDM2. By inhibiting MDM2, p53 is activated, subsequently modulating its downstream effectors. JNJ-26854165, RG7112, YK-3-237, and SAR405838 are examples of such compounds. They disrupt the p53-MDM2 association, leading to p53's activation and potential modulation of related proteins. Additionally, some compounds, like Stattic, influence proteins such as STAT3, which have known interactions with the p53 pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pifithrin-α hydrobromide | 63208-82-2 | sc-45050 sc-45050A | 5 mg 25 mg | $118.00 $287.00 | 36 | |
Acts as a p53 inhibitor and can affect related proteins or pathways wherein Trp53i13 may play a role. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $127.00 $192.00 $269.00 $502.00 $717.00 $1380.00 $2050.00 | 114 | |
Inhibits STAT3, a protein which has cross-talk with p53 pathways. This may indirectly affect Trp53i13's function or expression. | ||||||
PX 12 | 141400-58-0 | sc-358518 sc-358518A | 10 mg 50 mg | $130.00 $495.00 | 9 | |
By inhibiting thioredoxin-1, it modulates p53-dependent pathways which might have an impact on Trp53i13. | ||||||
JNJ 26854165 | 881202-45-5 | sc-364514 sc-364514A | 5 mg 25 mg | $168.00 $566.00 | ||
Acts as an antagonist to MDM2, activating p53 and potentially influencing related proteins, which can include Trp53i13. | ||||||
RG-7112 | 939981-39-2 | sc-507292 | 10 mg | $520.00 | ||
An MDM2 inhibitor, it can activate p53 and thereby influence proteins associated with the p53 pathway, including Trp53i13. | ||||||