Tropomyosin 4 Inhibitors
Tropomyosin 4 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of the tropomyosin 4 protein, a member of the tropomyosin family involved in regulating the actin cytoskeleton. Tropomyosin 4 plays a critical role in stabilizing actin filaments and controlling their interactions with other actin-binding proteins. This protein is important in cellular processes such as maintaining cell shape, supporting intracellular transport, and modulating cell movement. By binding to actin filaments, tropomyosin 4 helps to regulate the assembly and disassembly of the cytoskeleton, which is crucial for cell structure and mechanical integrity. Inhibitors of tropomyosin 4 disrupt these interactions, impairing the protein's ability to stabilize actin filaments and altering cytoskeletal dynamics.
Chemically, tropomyosin 4 inhibitors are designed to interact with specific regions of the protein that are responsible for its binding to actin. These inhibitors may block the actin-binding domains of tropomyosin 4, preventing it from associating with actin filaments and regulating their stability. The design of these compounds often emphasizes specificity, ensuring that they selectively target tropomyosin 4 without affecting other tropomyosin isoforms or actin-regulatory proteins. Researchers studying tropomyosin 4 inhibitors aim to better understand the unique roles that this isoform plays in cytoskeletal regulation and how inhibiting its activity affects broader cellular processes like migration, adhesion, and mechanical response. By examining the effects of these inhibitors, scientists can gain insights into the molecular mechanisms that control actin filament dynamics and how proteins like tropomyosin 4 contribute to maintaining cellular architecture and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A may inhibit TPM4 expression by disrupting actin polymerization. Inhibition of actin polymerization could lead to destabilization of actin filaments, subsequently downregulating the need for TPM4 in stabilizing actin filaments. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin may inhibit TPM4 expression by acting as a selective inhibitor of myosin II ATPase activity. Inhibition of myosin II ATPase activity could lead to a reduction in actin-myosin interaction, subsequently reducing the need for TPM4 in regulating muscle contraction. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D may inhibit TPM4 expression by disrupting actin polymerization. Inhibition of actin polymerization could lead to destabilization of actin filaments, subsequently downregulating the need for TPM4 in stabilizing actin filaments. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 may inhibit TPM4 expression by acting as an inhibitor of the Arp2/3 complex. Inhibition of the Arp2/3 complex could lead to disruption in actin filament branching and dynamics, subsequently downregulating the need for TPM4 in stabilizing actin filaments. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 may inhibit TPM4 expression by acting as a selective inhibitor of Rho-associated protein kinase (ROCK). Inhibition of ROCK could lead to a reduction in actin-myosin interaction and actin cytoskeleton organization, subsequently reducing the need for TPM4 in regulating muscle contraction. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 may inhibit TPM4 expression by acting as an inhibitor of the Arp2/3 complex. Inhibition of the Arp2/3 complex could lead to disruption in actin filament branching and dynamics, subsequently downregulating the need for TPM4 in stabilizing actin filaments. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide may inhibit TPM4 expression by stabilizing actin filaments, which may lead to a reduction in the requirement for TPM4 in stabilizing actin filaments. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 may inhibit TPM4 expression by acting as an inhibitor of formin-dependent actin polymerization. Inhibition of formin-dependent actin polymerization could lead to a reduction in actin filament formation, subsequently downregulating the need for TPM4 in stabilizing actin filaments. | ||||||
CK-689 | 170930-46-8 | sc-507371 | 25 mg | $312.00 | ||
CK-689 may inhibit TPM4 expression by acting as an inhibitor of the Arp2/3 complex. Inhibition of the Arp2/3 complex could lead to disruption in actin filament branching and dynamics, subsequently downregulating the need for TPM4 in stabilizing actin filaments. | ||||||