tropomodulin 1 Inhibitors
Chemical inhibitors of tropomodulin 1 operate through diverse mechanisms to affect its ability to cap actin filaments. Colchicine, a compound known to bind to tubulin, disrupts the polymerization of microtubules, which can indirectly inhibit tropomodulin 1 by destabilizing components of the cytoskeleton that may affect actin filament dynamics. Similarly, drugs like Paclitaxel, Vinblastine, Vincristine, Nocodazole, and Podophyllotoxin, which target microtubules through various means of stabilization or depolymerization, can also indirectly impede the function of tropomodulin 1 by altering the overall balance and interactions of the cytoskeletal network. The changes in microtubule dynamics brought about by these chemicals likely influence the structural context within which tropomodulin 1 operates, thereby impacting its role in actin capping.
On the other hand, certain chemicals directly target the actin filaments, which are the primary substrates for tropomodulin 1's capping activity. Cytochalasin D and Latrunculin A interfere with actin polymerization by binding to the filaments' ends and monomers, respectively, which can inhibit tropomodulin 1 by altering the availability of actin for capping. Swinholide A and Chondramide also affect actin structure by severing filaments or preventing their polymerization, which can similarly disrupt the normal function of tropomodulin 1 by changing the natural landscape of actin filaments it is meant to cap. Each of these chemicals, through their unique interactions with actin or tubulin, can modulate the biological activity of tropomodulin 1 and influence its capping capability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, disrupting microtubule polymerization, which can inhibit tropomodulin 1 by destabilizing microtubules, thus indirectly inhibiting the capping ability of tropomodulin 1 on actin filaments. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can indirectly inhibit tropomodulin 1 by altering microtubule dynamics and potentially affecting the actin cytoskeleton network where tropomodulin 1 exerts its function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, blocking polymerization and elongation. This action can inhibit tropomodulin 1 by preventing it from binding to the pointed end, as the normal filament dynamics are disrupted. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers, sequestering them and preventing their polymerization. This process can inhibit tropomodulin 1 by reducing the available actin for capping at the pointed end. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A severs actin filaments and caps the barbed ends, which can indirectly inhibit tropomodulin 1 by disrupting the actin cytoskeleton and preventing the normal capping of the pointed ends by tropomodulin 1. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits its polymerization, which can indirectly inhibit tropomodulin 1 by affecting microtubule dynamics and potentially the associated actin filament networks. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can indirectly inhibit tropomodulin 1 by altering microtubule dynamics, which in turn may affect the spatial organization and dynamics of actin filaments. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits microtubule assembly, which can indirectly inhibit tropomodulin 1 by changing the dynamics of the cytoskeleton and influencing the actin filament capping activity. | ||||||