TRIP12 Activators
The chemical class, TRIP12 Activators, primarily includes proteasome inhibitors such as MG132, Epoxomicin, Lactacystin, Bortezomib, Carfilzomib, and MLN2238. These compounds inhibit the degradation of ubiquitinated proteins, which can indirectly influence the ubiquitination activity of TRIP12. The accumulation of ubiquitinated proteins can stimulate TRIP12's E3 ubiquitin ligase activity, leading to a higher demand for ubiquitin tagging of proteins. For instance, MG132, Epoxomicin, and Lactacystin are potent proteasome inhibitors that prevent the degradation of ubiquitinated proteins, thereby potentially stimulating TRIP12's E3 ubiquitin ligase activity. Similarly, Bortezomib, Carfilzomib, andMLN2238 are also proteasome inhibitors that block the degradation of ubiquitinated proteins, which can lead to an indirect stimulation of TRIP12's E3 ubiquitin ligase activity.
In addition to proteasome inhibitors, this class also encompasses autophagy inhibitors and Src inhibitors that can indirectly affect the ubiquitin-proteasome system, thereby potentially stimulating TRIP12's ubiquitin ligase activity. Autophagy inhibitors such as Chloroquine, 3-Methyladenine, Wortmannin, and LY294002 inhibit the autophagy pathway, which works in tandem with the ubiquitin-proteasome system. Inhibition of autophagy shifts the balance towards proteasomal degradation, potentially stimulating TRIP12's ubiquitin ligase activity. On the other hand, Src inhibitors like Saracatinib and Dasatinib inhibit Src, leading to the accumulation of ubiquitinated proteins, which may stimulate TRIP12's ubiquitin ligase activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. The accumulation of these proteins could promote TRIP12 to increase its ubiquitination activity. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
Carfilzomib, another proteasome inhibitor, prevents the degradation of ubiquitinated proteins. This could result in a higher demand for ubiquitin tagging, thereby potentially stimulating TRIP12's E3 ubiquitin ligase activity. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
Ixazomib is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. This could stimulate TRIP12's E3 ubiquitin ligase activity by creating a higher demand for ubiquitin tagging. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to inhibit autophagy, a process that works in tandem with the ubiquitin-proteasome system. Inhibition of this pathway could shift the balance towards proteasomal degradation, potentially stimulating TRIP12's ubiquitination activity. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine is an autophagy inhibitor. By inhibiting autophagy, it could increase the demand for proteasomal degradation, possibly stimulating TRIP12's E3 ubiquitin ligase activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor which also inhibits autophagy. The inhibition of autophagy could potentially stimulate TRIP12's ubiquitin ligase activity by increasing the demand for proteasomal degradation. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $115.00 $1056.00 | 7 | |
Saracatinib is a Src inhibitor that can indirectly affect the ubiquitin-proteasome system. Src inhibition can lead to the accumulation of ubiquitinated proteins, which may stimulate TRIP12's ubiquitin ligase activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a Src inhibitor that can indirectly affect the ubiquitin-proteasome system. By inhibiting Src, it can lead to the accumulation of ubiquitinated proteins, which may stimulate TRIP12's ubiquitin ligase activity. | ||||||