TREM-5 Inhibitors
TREM-5 Inhibitors operate through various mechanisms to reduce the functional activity of TREM-5, a protein implicated in the immune response. Compounds such as Cyclosporine A and Dexamethasone work by modulating the immune system's response at the transcriptional level. Cyclosporine A achieves this by inhibiting the phosphatase activity of calcineurin, which is necessary for the activation of NFAT, a critical transcription factor for the upregulation of immune response genes, including those encoding TREM-5. Dexamethasone, a corticosteroid, acts by suppressing the transcription of genes responsible for inflammatory responses, thereby hindering the synthesis of TREM-5. Similarly, NF-κB pathway inhibitors, such as IKK-16 and BAY 11-7082, prevent the transcription of NF-κB target genes, likely reducing TREM-5 expression by preventing NF-κB from initiating the transcription of inflammatory response genes.
Other inhibitors target various signaling pathways that indirectly influence TREM-5 activity. PI3K inhibitors like LY294002 and Wortmannin, as well as mTOR inhibitor Rapamycin, lead to a decrease in cell proliferation and protein synthesis, which includes the downregulation of immune response proteins such as TREM-5. MEK inhibitors PD98059 and U0126, along with the JNK inhibitorSP600125 and the p38 MAPK inhibitor SB203580, reduce the expression of pro-inflammatory cytokines and proteins by blocking the MAPK/ERK and JNK signaling pathways. The overall effect of these inhibitors is a coordinated downregulation of the pathways and processes that lead to the expression and functional activity of TREM-5, demonstrating the intricate interplay of cellular signaling in regulating protein function.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
An immunosuppressant that inhibits calcineurin. By blocking calcineurin, Cyclosporine A prevents the dephosphorylation and activation of NFAT (Nuclear Factor of Activated T-cells), a transcription factor that could upregulate the expression of TREM-5 by promoting the transcription of its gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, which, when inhibited, leads to decreased protein synthesis and cell proliferation. As TREM-5 is part of the immune response, inhibiting mTOR can lead to a reduced expression of immune response genes, including TREM-5. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that impedes the PI3K/AKT/mTOR signaling pathway. Inhibition of this pathway can decrease activation of downstream transcription factors responsible for the expression of immune response proteins such as TREM-5. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor, similar to LY294002, Wortmannin can lead to the suppression of TREM-5 expression by inhibiting the activation of signaling pathways involved in immune cell activation and proliferation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that blocks the MAPK/ERK pathway, potentially reducing the expression of genes involved in the inflammatory response, including TREM-5. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of MEK1/2, which impedes the MAPK/ERK signaling pathway. This can lead to decreased expression of TREM-5 by limiting pro-inflammatory signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that can reduce the expression of pro-inflammatory cytokines and other proteins involved in the immune response, such as TREM-5, by inhibiting JNK signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that may decrease the expression of TREM-5 by inhibiting the pathway involved in stress and inflammatory responses. | ||||||
IKK 16 | 1186195-62-9 | sc-204009 sc-204009A | 10 mg 50 mg | $219.00 $924.00 | 2 | |
An inhibitor of IKK, which is necessary for the activation of NF-κB. Inhibition of IKK can prevent the expression of NF-κB target genes, potentially including TREM-5. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
An NF-κB inhibitor that prevents the phosphorylation and subsequent degradation of IκBα, thereby inhibiting the release and translocation of NF-κB to the nucleus. This reduces the expression of NF-κB responsive genes such as TREM-5. | ||||||