TRAP100 Inhibitors
TRAP100 inhibitors, as considered here, primarily target pathways and processes associated with transcription and RNA processing, given the protein's role in pre-mRNA 3'-end processing. Among the chemicals listed, Flavopiridol and DRB are CDK9 inhibitors that can impede transcription and related pre-mRNA processing. Their impact on RNA polymerase II function suggests a influence on proteins like TRAP100 that engage in RNA processing. α-amanitin and Triptolide are direct inhibitors of RNA polymerase II, and their action can influence all downstream RNA processing events, affecting the function and involvement of TRAP100.
Actinomycin D presents a broader approach, interfering with transcription by binding directly to DNA, while JQ1, a modulator of bromodomain proteins, can have indirect effects on RNA processing. Highlighting the importance of RNA splicing in relation to TRAP100's function, several chemicals like Pladienolide B, Spliceostatin A, Meayamycin, Sudemycin E, and H3B-8800 are known to influence the spliceosome, a complex essential for RNA splicing. Their effects on this machinery might have ripple effects, influencing other RNA processing factors like TRAP100.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
CDK9 inhibitor that can affect transcription and pre-mRNA processing. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibitor of CDK9, potentially impacting RNA polymerase II and linked RNA processing. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
RNA polymerase II inhibitor, influencing transcription and subsequently RNA processing. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Inhibits RNA polymerase II, affecting transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interferes with transcription by binding DNA. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
Affects bromodomain proteins which can indirectly influence RNA processing. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Inhibits the spliceosome, which is central to pre-mRNA processing. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Binds to the spliceosome, affecting RNA splicing. | ||||||