TP53INP2 Inhibitors
TP53INP2 inhibitors belong to a specific chemical class of compounds that are designed to target and modulate the activity of the TP53INP2 protein. TP53INP2, also known as tumor protein 53-inducible nuclear protein 2, is a multifunctional protein that plays a crucial role in regulating various cellular processes. These inhibitors are synthetic molecules carefully crafted to interact with TP53INP2 and inhibit its function. The exact mechanisms of action of TP53INP2 inhibitors may vary, but they are designed to bind to specific regions of the protein, thereby disrupting its normal activity. TP53INP2 itself is an important factor in cellular responses to stress and DNA damage, and it is involved in the regulation of autophagy and apoptosis. By targeting TP53INP2, these inhibitors have the potential to modulate these cellular pathways and impact cell behavior.
The development of TP53INP2 inhibitors has been a subject of considerable research and interest in the scientific community, driven by the understanding of TP53INP2's significant involvement in various cellular processes and its potential implications in disease. Researchers are actively exploring the chemical structures and properties of TP53INP2 inhibitors to optimize their effectiveness and selectivity. The goal is to develop potent and specific inhibitors that can be used as valuable tools in basic research to study TP53INP2 function further. Understanding the role of TP53INP2 and its modulation by inhibitors may shed light on the molecular mechanisms underlying cellular responses to stress and DNA damage. This knowledge can potentially contribute to a broader understanding of cell biology and signal transduction pathways. Overall, TP53INP2 inhibitors represent a promising avenue for targeted research, aiming to elucidate the intricacies of cellular regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pifithrin-α hydrobromide | 63208-82-2 | sc-45050 sc-45050A | 5 mg 25 mg | $120.00 $300.00 | 36 | |
Pifithrin-α(HBr) is a small molecule inhibitor that has been shown to inhibit p53-mediated apoptosis and block the transactivation of p53 target genes, including TP53INP2. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 is a well-known small molecule inhibitor that disrupts the interaction between p53 and its negative regulator, MDMIt results in the stabilization of p53 and activation of its downstream target genes, including TP53INP2. | ||||||
p53 Activator III, RITA | 213261-59-7 | sc-202753 sc-202753A sc-202753B sc-202753C | 1 mg 10 mg 100 mg 500 mg | $112.00 $273.00 $1564.00 $5205.00 | 9 | |
RITA-1 is a derivative of RITA and is known for its p53-activating properties. It can trigger apoptosis in cancer cells, which may involve TP53INP2 upregulation. | ||||||
PRIMA-1 | 5608-24-2 | sc-200927 sc-200927A | 5 mg 25 mg | $102.00 $408.00 | 1 | |
PRIMA-1, also known as PRIMA-1Met or APR-246, is a compound that restores the transcriptional activity of mutant p53 and promotes cancer cell death. TP53INP2 might be among the genes affected by this reactivation. | ||||||
CP 31398 dihydrochloride | 259199-65-0 | sc-205270 sc-205270A | 10 mg 50 mg | $109.00 $434.00 | ||
CP-31398 is another small molecule that has been reported to rescue the function of mutant p53, leading to apoptosis in cancer cells. This reactivation could influence TP53INP2 expression. | ||||||
NSC 319726 | 71555-25-4 | sc-477736 | 10 mg | $159.00 | ||
NSC319726 is a small molecule inhibitor that was found to stabilize p53 and induce apoptosis in tumor cells, potentially affecting TP53INP2 levels. | ||||||
PhiKan-083 Hydrochloride | 880813-36-5 | sc-479264 | 10 mg | $320.00 | ||
PhiKan083 is a novel small molecule inhibitor that has been reported to promote p53-dependent apoptosis in cancer cells, possibly involving TP53INP2 activation. | ||||||