TNRC6B Activators
TNRC6B activators are a class of compounds that specifically target TNRC6B, a protein involved in the RNA interference (RNAi) pathway. This pathway is crucial for the regulation of gene expression at the post-transcriptional level. TNRC6B, also known as GW182, is a key component of the RNA-induced silencing complex (RISC), which is responsible for guiding the degradation of target mRNAs or inhibiting their translation. By activating TNRC6B, these compounds can modulate the RNAi pathway, leading to changes in gene expression profiles.
The mechanism of action of TNRC6B activators involves their interaction with TNRC6B protein, which may lead to conformational changes that enhance its binding affinity to other components of the RISC complex or increase its stability. This, in turn, can promote the efficiency of mRNA degradation or translational repression, depending on the specific context. By modulating the RNAi pathway through TNRC6B activation, these compounds have the potential to influence various cellular processes, including development, differentiation, and response to external stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Enoxacin | 74011-58-8 | sc-205670 sc-205670A | 500 mg 1 g | $40.00 $49.00 | 2 | |
A fluoroquinolone that can enhance miRNA processing and function, possibly increasing the functional demand on TNRC6B as a component of miRISC. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor that can lead to an altered chromatin state and affect miRNA expression, potentially modulating TNRC6B activity through changes in miRNA profiles. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
DNA methyltransferase inhibitor that can modulate miRNA expression, likely influencing TNRC6B activity through its role in miRISC. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone that acts as a tyrosine kinase inhibitor and can modify various signaling pathways, potentially altering miRNA expression and subsequently TNRC6B function in miRNA-induced silencing. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
Another DNA methyltransferase inhibitor that can change miRNA expression profiles, which can indirectly enhance the role of TNRC6B in miRNA-mediated gene silencing. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Donor of methyl groups in numerous methylation reactions, including those that can modify miRNA expression. Changes in miRNA expression can alter the demand for TNRC6B in the miRISC. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $112.00 $459.00 | 8 | |
Activates NQO1 which affects p53 signaling, this can lead to changes in miRNA profiles that implicate TNRC6B in the miRISC. | ||||||
DL-α-Tocopherol | 10191-41-0 | sc-294383 sc-294383A sc-294383B sc-294383C | 5 g 25 g 100 g 500 g | $26.00 $52.00 $124.00 $326.00 | 3 | |
An antioxidant that may affect miRNA expression through modulation of oxidative stress signaling pathways, potentially affecting TNRC6B activity. | ||||||