TMEM220 Inhibitors
TMEM220 may contain inhibitors like Genistein, a tyrosine kinase inhibitor, which can impede phosphorylation events that are fundamental for the activation and regulation of many proteins, including transmembrane proteins similar to TMEM220. Brefeldin A and Dynasore can disrupt protein trafficking to and from the membrane, respectively, which can be critical for the proper localization and function of TMEM220.
Compounds like Cholesterol and Filipin III target the lipid environment of the plasma membrane, which is vital for the structural and functional integrity of membrane proteins. Altering the balance of membrane lipids with GW4869 or the ion gradients with Monensin can lead to changes in the microenvironment and ion homeostasis, respectively, potentially affecting the stability and activity of TMEM220. Inhibitors such as U73122 and PD98059 target upstream signaling molecules like phospholipase C and MEK, respectively, which are part of larger signaling cascades that can influence the regulation of TMEM220. ML-7, Calphostin C, and Gö6976 can affect the cytoskeletal architecture and kinase-mediated signaling pathways, potentially leading to alterations in TMEM220's cellular interactions and regulatory mechanisms.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone that acts as a tyrosine kinase inhibitor, potentially disrupting phosphorylation events that could regulate TMEM220. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
An inhibitor of ADP-ribosylation factor, which disrupts protein transport and could affect TMEM220 trafficking to the membrane. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A dynamin inhibitor, potentially hindering endocytosis and the internalization of TMEM220 from the plasma membrane. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Essential for membrane fluidity and integrity; altering cholesterol levels can modulate the membrane environment of TMEM220. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
A polyene that binds to cholesterol, potentially disrupting lipid rafts and TMEM220's localization within the membrane. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
An inhibitor of sphingomyelinase, affecting sphingolipid metabolism and potentially altering the microenvironment of TMEM220. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
An ionophore that disrupts intracellular pH and ion gradients, which can affect TMEM220's conformation and function. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
An inhibitor of myosin light chain kinase, which can affect cytoskeletal dynamics and potentially influence TMEM220's cellular context. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
A potent inhibitor of protein kinase C, which could alter downstream signaling that might regulate TMEM220. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
A classic protein kinase C inhibitor, potentially altering signaling pathways that could affect TMEM220 regulation. | ||||||