Date published: 2026-4-1

1-800-457-3801

SCBT Portrait Logo
Seach Input

TMEM200A Activators

Chemical activators of TMEM200A include a variety of compounds that can induce a change in the protein's activity. Calcium chloride provides calcium ions, which can directly activate TMEM200A by stabilizing its conformation, promoting interactions with other cellular components essential for its function. Similarly, magnesium sulfate supplies magnesium ions necessary for many cellular processes, including the proper folding and function of TMEM200A, leading to its activation. Sodium orthovanadate, by inhibiting phosphatases, can prevent the dephosphorylation of TMEM200A, thereby maintaining it in an activated state. Forskolin, through its action on adenylyl cyclase, increases intracellular cAMP levels. This elevation in cAMP can activate protein kinase A, which may then phosphorylate TMEM200A, contributing to its activation process.

The activation of TMEM200A is further modulated by other chemicals that influence cellular signaling pathways. Ionomycin, by elevating intracellular calcium levels, can also activate TMEM200A, indicating the protein's potential reliance on calcium for activation. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C, which can phosphorylate TMEM200A, leading to its activation. Zinc acetate and Copper(II) sulfate provide zinc and copper ions, respectively, which can bind to TMEM200A and induce a conformational change that results in protein activation. ATP serves as a substrate for phosphorylation reactions or induces structural modifications required for TMEM200A activation. Sodium fluoride acts by maintaining the phosphorylation state of TMEM200A through the inhibition of phosphatases. Hydrogen peroxide can activate TMEM200A through oxidative signaling pathways that alter the protein's structure and function. Lastly, a nitric oxide donor such as S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide, which can lead to the activation of TMEM200A by way of increased cyclic GMP levels or via a cGMP-dependent kinase signaling pathway.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Calcium chloride anhydrous

10043-52-4sc-207392
sc-207392A
100 g
500 g
$66.00
$262.00
1
(1)

Calcium ions from Calcium chloride can directly activate TMEM200A by stabilizing the protein's conformation, enabling it to interact with other cellular components essential for its function, thereby facilitating the activation process.

Magnesium sulfate anhydrous

7487-88-9sc-211764
sc-211764A
sc-211764B
sc-211764C
sc-211764D
500 g
1 kg
2.5 kg
5 kg
10 kg
$46.00
$69.00
$163.00
$245.00
$418.00
3
(1)

Magnesium ions are critical for many cellular processes. Magnesium sulfate can provide these ions, which may bind to TMEM200A, facilitating its proper folding and function, resulting in its activation.

Sodium Orthovanadate

13721-39-6sc-3540
sc-3540B
sc-3540A
5 g
10 g
50 g
$49.00
$57.00
$187.00
142
(4)

Sodium orthovanadate acts as a phosphatase inhibitor and can lead to the activation of TMEM200A by preventing its dephosphorylation, which is a common regulatory mechanism for maintaining a protein in its active state.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$78.00
$270.00
80
(4)

Ionomycin is a calcium ionophore that can raise intracellular calcium levels, which may lead to the activation of TMEM200A due to the protein's potential dependence on calcium for its activation.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates protein kinase C (PKC), which may then phosphorylate TMEM200A, leading to its activation.

Zinc

7440-66-6sc-213177
100 g
$48.00
(0)

Zinc ions from Zinc acetate can bind to specific sites on TMEM200A, inducing a conformational change that leads to its activation.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$46.00
$122.00
$189.00
3
(1)

Copper ions from Copper(II) sulfate may act as allosteric activators of TMEM200A, binding to the protein and inducing a conformational shift that leads to its activation.

ADP

58-64-0sc-507362
5 g
$54.00
(0)

ATP can directly activate TMEM200A by serving as a substrate for phosphorylation or by inducing conformational changes that are required for the protein's activation.

Sodium Fluoride

7681-49-4sc-24988A
sc-24988
sc-24988B
5 g
100 g
500 g
$40.00
$46.00
$100.00
26
(4)

Sodium fluoride is a known activator of various enzymes and may activate TMEM200A by inhibiting phosphatases that would otherwise dephosphorylate and deactivate TMEM200A, thereby maintaining TMEM200A in an active state.

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$31.00
$61.00
$95.00
28
(1)

Hydrogen peroxide can act as a signaling molecule, and in certain contexts, it can lead to the activation of TMEM200A through oxidative signaling pathways that modify the protein's structure and activity.