TMEM167 Inhibitors
Inhibition of TMEM167 can be approached through the modulation of various cellular pathways that impact its activity. Compounds targeting glucose transporters, such as those that inhibit GLUT1, can indirectly reduce TMEM167 activity by depriving cells of glucose, a critical energy source necessary for many cellular functions TMEM167 might be involved in. Inhibition of tyrosine kinase and phospholipase C, on the other hand, alters cell signaling cascades that could regulate the phosphorylation state or second messenger production, respectively, potentially affecting TMEM167's regulation if it is modulated by such signaling molecules. The PI3K/Akt pathway, a well-known signaling pathway involved in cell survival and metabolism, can be influenced by specific inhibitors that hinder the activity of PI3K, thus potentially reducing TMEM167 activity if it is regulated by this pathway. Similarly, inhibition of the MEK component of the MAPK/ERK pathway and selective inhibition of p38 MAP kinase can modulate TMEM167 function if these pathways exert control over the protein.
Furthermore, inhibition of key enzymes such as Protein Kinase C (PKC) through the use of potent PKC inhibitors can lead to a downstream reduction in TMEM167 activity if it is regulated by PKC-mediated signaling. Broad-spectrum inhibitors of PKC would have a similar impact on TMEM167 by affecting various PKC-dependent pathways. The activity of mTOR, a central component of the PI3K/Akt/mTOR signaling pathway, can be inhibited by specific compounds, potentially leading to reduced TMEM167 activity if it lies downstream of mTOR signaling. Lastly, the process of autophagy, which plays a significant role in cellular homeostasis and protein degradation, can be modulated by agents that either promote or inhibit this pathway.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
This compound inhibits the activity of various glucose transporters, thereby reducing the availability of glucose in cells. TMEM167 associated processes that may require glucose could be indirectly inhibited as a result of reduced glucose uptake. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
As a glucose transporter 1 (GLUT1) inhibitor, this compound decreases glucose uptake, potentially affecting the cellular processes that TMEM167 is involved in which may rely on glucose for proper functioning. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As a tyrosine kinase inhibitor, Genistein can alter phosphorylation states of proteins within cells. If TMEM167 is regulated by phosphorylation, its activity could be indirectly inhibited by this compound through altered cell signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
An inhibitor of PI3K, LY 294002 impacts the PI3K/Akt signaling pathway. Since TMEM167 might be regulated by this pathway, its activity could be reduced when this pathway is inhibited. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
By inhibiting MEK, which is part of the MAPK/ERK pathway, PD 98059 could indirectly affect TMEM167 if its function is regulated by this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This compound selectively inhibits p38 MAP kinase. If TMEM167 activity is influenced by the p38 MAPK signaling pathway, then its activity could be indirectly reduced by this inhibitor. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
As an inhibitor of phosphoinositide 3-kinases, Wortmannin can impact various signaling pathways including those that may regulate TMEM167, leading to its indirect inhibition. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
This compound is a potent inhibitor of Protein Kinase C (PKC). If TMEM167 is regulated by PKC-mediated pathways, its activity could be inhibited by altering the signaling cascade. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a broad-spectrum PKC inhibitor and could indirectly inhibit TMEM167 if it is regulated by PKC-dependent signaling pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the PI3K/Akt/mTOR pathway. Inhibition of this pathway could lead to reduced activity of TMEM167 if it is downstream of or influenced by mTOR signaling. | ||||||