TMEM138 Inhibitors
Chemical inhibitors of TMEM138 can act through various mechanisms to disrupt its function in cellular processes, particularly in ciliogenesis and ciliary maintenance. Alsterpaullone, as a cyclin-dependent kinase inhibitor, can inhibit the cell cycle regulation pathways essential for the proper functioning of TMEM138, which is crucial for ciliary development. Similarly, Zoledronic acid's inhibition of farnesyl pyrophosphate synthase can impair prenylation, a post-translational modification necessary for membrane association of proteins; TMEM138, being a ciliary membrane-associated protein, can have its function inhibited due to disrupted prenylation. Perhexiline's action on carnitine palmitoyltransferase 1 can alter lipid metabolism, which may affect the lipid composition of the ciliary membrane where TMEM138 is localized, thereby impacting its function. Thapsigargin raises cytosolic calcium levels by inhibiting the SERCA pump, potentially affecting ciliogenesis and the function of TMEM138 in this process.
Furthermore, chemical inhibitors such as Brefeldin A can disrupt Golgi function and vesicular trafficking, essential for the transport of proteins like TMEM138 to the cilium. Cytochalasin D can inhibit TMEM138 by interfering with actin polymerization, which is necessary for ciliogenesis and the trafficking of proteins to the ciliary base. Dynasore affects endocytosis and vesicular trafficking by inhibiting the GTPase activity of dynamin; this could disrupt the trafficking routes essential for the ciliary function of TMEM138. Colchicine binds to tubulin, preventing its polymerization into microtubules, which are integral to the ciliary structure, thus potentially inhibiting TMEM138 function due to disrupted microtubule architecture. Chlorpromazine's inhibition of calmodulin, involved in calcium signaling pathways, can influence TMEM138's role in ciliogenesis. Genistein, by inhibiting tyrosine kinase, can affect signaling pathways that regulate ciliary function, where TMEM138 is involved. Lastly, Mitomycin C can disrupt cell cycle progression by crosslinking DNA, and Paclitaxel can aberrantly stabilize microtubules; both of these effects can inhibit TMEM138's involvement in ciliary dynamics and function.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that can inhibit TMEM138 by disrupting cell cycle regulation pathways that TMEM138 is involved in, particularly those that mediate its function in ciliogenesis and ciliary maintenance. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic acid is a bisphosphonate that can inhibit farnesyl pyrophosphate synthase, potentially impairing prenylation and subsequent membrane association of proteins. TMEM138, being associated with the ciliary membrane, could have its function inhibited due to disrupted prenylation and membrane attachment. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $184.00 | ||
Perhexiline inhibits carnitine palmitoyltransferase 1, which could lead to altered lipid metabolism. Since TMEM138 is involved in the formation and function of primary cilia, which are sensitive to changes in lipid compositions of the ciliary membrane, this could inhibit the proper functioning of TMEM138. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump inhibitor which leads to increased cytosolic calcium levels. Elevated intracellular calcium can affect ciliary beat frequency and ciliogenesis, potentially inhibiting the function of TMEM138 in the process of ciliogenesis. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi function and vesicular trafficking, which is essential for the transport of proteins to the cilium. TMEM138 function could be inhibited as it may rely on this trafficking for proper localization to the cilium. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin polymerization, potentially inhibiting TMEM138 by interfering with the actin cytoskeleton's role in ciliogenesis and trafficking to the ciliary base, processes in which TMEM138 is involved. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a GTPase inhibitor for dynamin, affecting endocytosis and vesicular trafficking. TMEM138, which is part of the IFT-A complex involved in retrograde intraflagellar transport, could be functionally inhibited by the disruption of trafficking routes essential for its ciliary function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, which are crucial components of the ciliary structure. TMEM138 is implicated in ciliary development and function, and its inhibition could arise due to the disrupted microtubule architecture within cilia. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine can inhibit calmodulin, which plays a role in calcium signaling pathways. Since calcium signaling is critical for ciliogenesis and ciliary function, and TMEM138 is involved in these processes, the inhibition of calmodulin could lead to functional inhibition of TMEM138. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that could inhibit TMEM138 by disrupting tyrosine kinase-dependent signaling pathways that regulate ciliogenesis and ciliary function, processes in which TMEM138 is critical. | ||||||