Date published: 2026-4-14

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Thrombin R Inhibitors

Thrombin R inhibitors represent a chemically diverse class of compounds that specifically target the thrombin receptor, also known as protease-activated receptor 1 (PAR-1). Thrombin, a serine protease, serves as a central player in the coagulation cascade and cellular signaling. When thrombin interacts with the thrombin receptor, it cleaves the receptor's extracellular domain, resulting in the exposure of a tethered ligand that binds back to the receptor's cleaved site. This event triggers intracellular signaling cascades, leading to various cellular responses, including platelet activation, inflammation, and tissue repair.Thrombin R inhibitors are carefully designed to interfere with the thrombin-receptor interaction, effectively preventing thrombin from binding to the receptor and initiating downstream signaling pathways. By blocking thrombin receptor activation, these inhibitors disrupt the signaling events that follow, influencing coagulation, inflammation, and other physiological processes involving the thrombin receptor. The diverse chemical structures within this class offer researchers valuable tools for studying thrombin receptor signaling in a controlled and selective manner. Scientists can use these inhibitors to elucidate the specific roles of the thrombin receptor in cellular physiology and to better understand its involvement in various diseases and pathological conditions. As essential research tools, thrombin R inhibitors provide insights into the intricacies of cellular signaling pathways, thrombin-mediated responses, and their relevance to normal physiological processes and disease states. The understanding gained from studying these inhibitors can guide further investigations into the molecular mechanisms governing thrombin receptor signaling.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

FR 171113

173904-50-2sc-361180
sc-361180A
10 mg
50 mg
$203.00
$859.00
(0)

FR 171113 is a thrombin receptor inhibitor targeting protease-activated receptor 1 (PAR-1). Thrombin activates PAR-1 through cleavage, leading to various cellular responses. FR 171113 specifically blocks this activation by interfering with the thrombin-PAR-1 interaction.

Dabigatran

211914-51-1sc-481166
5 mg
$205.00
1
(0)

Dabigatran is a direct thrombin inhibitor that works by binding to and inhibiting the activity of thrombin, an enzyme involved in the clotting process. By inhibiting thrombin, dabigatran prevents the formation of fibrin, a protein that helps in the formation of blood clots.

SCH 79797 dihydrochloride

1216720-69-2sc-203693
sc-203693A
10 mg
50 mg
$354.00
$1418.00
13
(1)

SCH 79797 dihydrochloride is a thrombin receptor (protease-activated receptor 1 or PAR-1) inhibitor designed to target thrombin-induced receptor activation. Thrombin, a serine protease, triggers cellular responses by cleaving and activating PAR-1. SCH 79797 dihydrochloride blocks this activation process by interfering with the thrombin-PAR-1 interaction.

Rivaroxaban

366789-02-8sc-208311
2 mg
$158.00
18
(1)

Rivaroxaban is a factor Xa inhibitor that works by binding to and inhibiting the activity of factor Xa, an enzyme involved in the clotting process. By inhibiting factor Xa, rivaroxaban prevents the conversion of prothrombin to thrombin, thereby reducing the formation of blood clots.

Apixaban

503612-47-3sc-364406
sc-364406A
10 mg
50 mg
$240.00
$634.00
2
(1)

Apixaban is also a factor Xa inhibitor that works in a similar way to rivaroxaban. It binds to and inhibits the activity of factor Xa, reducing the formation of blood clots.

Edoxaban

480449-70-5sc-483508
25 mg
$522.00
(0)

Edoxaban is another factor Xa inhibitor that works by binding to and inhibiting the activity of factor Xa. By inhibiting factor Xa, edoxaban prevents the conversion of prothrombin to thrombin, reducing the formation of blood clots.

Argatroban

74863-84-6sc-201310
sc-201310A
10 mg
50 mg
$117.00
$469.00
13
(1)

Argatroban is a direct thrombin inhibitor that works by binding to and inhibiting the activity of thrombin. By inhibiting thrombin, argatroban prevents the formation of fibrin and reduces the formation of blood clots.

Bivalirudin

128270-60-0sc-278793
5 mg
$110.00
(0)

Bivalirudin is a direct thrombin inhibitor that works by binding to and inhibiting the activity of thrombin. By inhibiting thrombin, bivalirudin prevents the formation of fibrin and reduces the formation of blood clots.

Desirudin

120993-53-5sc-507332
50 mg
$2950.00
(0)

Desirudin is a direct thrombin inhibitor that works by binding to and inhibiting the activity of thrombin. By inhibiting thrombin, desirudin prevents the formation of fibrin and reduces the formation of blood clots.